T-CELL ACUTE LYMPHOBLASTIC-LEUKEMIA WITH T(11,14) IN CHILDREN

被引：3
作者：
RIBEIRO, RC
RAIMONDI, SC
BEHM, FG
PUI, CH
机构：
[1] Departments of Hematology-Oncology St. Jude Children's Research Hospital, Departments of Pediatrics and Pathology, University of Tennessee, Memphis
[2] College of Medicine, Memphis, TN
[3] Departments of Pathology and Laboratory Medicine, St. Jude Children's Research Hospital, and the Departments of Pediatrics and Pathology, University of Tennessee, Memphis
来源：
LEUKEMIA & LYMPHOMA | 1992年 / 7卷 / 5-6期
关键词：
T-ALL; T(11,14); PEDIATRIC ALL; ACUTE LEUKEMIA; TRANSLOCATION;
D O I：
10.3109/10428199209049790
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We review and update our examination of the clinical and biologic findings in 19 cases of acute lymphoblastic leukemia (ALL) with the t(11;14) and discuss the literature relevant to the clinical, biologic, and molecular aspects of these translocations. In nine consecutively diagnosed cases at St. Jude Children's Research Hospital and 10 cases reported by other institutions, clinical features did not differ among T-cell ALL patients with and without the t(11;14), although leukemic cells with this translocation were more likely to coexpress CD4 and CD8 antigens. The t(11;14)(p13;q11) appears to occur exclusively in T-cell malignancies of intermediate- or late-stage thymocyte differentiation; further studies will be needed to determine whether it has prognostic significance.
引用
收藏
页码：351 / 358
页数：8
相关论文
共 54 条
  • [51] Tycko B., Sklar J., Chromosomal translocations in lymphoid neoplasia: a reappraisal of the recombinase model, Cancer Cells, 2, pp. 1-8, (1990)
  • [52] Hope T.J., Aguilera R.J., Minie M.E., Sakano H., Endonucleolytic activity that cleaves immunoglobulin recombination sequences, Science, 231, pp. 1141-1145, (1986)
  • [53] Apian P.D., Lombardi D.P., Ginsberg A.M., Cossman J., Bertness V.L., Kirsch I.R., Disruption of the human SCL locus by “illegitimate” V-(D)-J recombinase activity, Science, 250, pp. 1426-1429, (1990)
  • [54] Rabbitts T.H., Boehm T., Structural and functional chimerism results from chromosomal translocation in lymphoid tumors, Advances in Immunology, 50, pp. 119-146, (1991)
123456