ACID PROPERTIES OF SOME PHOSPHONOCARBOXYLIC ACIDS

被引：19

作者：

HEUBEL, PHC ^{[1
]}

POPOV, AI ^{[1
]}

机构：

[1] MICHIGAN STATE UNIV,DEPT CHEM,E LANSING,MI 48824

来源：

JOURNAL OF SOLUTION CHEMISTRY | 1979年 / 8卷 / 09期

关键词：

2-phosphonopropionic acid; 3-phosphonopropionic acid; acid dissociation constants; carbon-13; NMR; Herpes virus; Phosphonoacetic acid; phosphonoformic acid; phosphorus-31; titration curves;

D O I：

10.1007/BF01033692

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Thermodynamic acid dissociation constants were determined for phosphonoacetic acid (PAA) in aqueous solution at 25°C by coulometric titrations at different ionic strengths and extrapolation of the results to I=0. The respective values are pK1∼2.0, pK2=5.11±0.04, and pK3=8.69±0.05. The enthalpy and entropy of dissociation for the second and the third dissociation steps, determined from the temperature dependence of pK's, are ΔH2o=0.2±0.3 kcal-mole-1, ΔS2o=22.6±0.9 e.u., ΔH3o=1.3±0.4 kcal-mole-1, and ΔS3o=11.7±0.4 e.u. Phosphorus-31 and carbon-13 NMR studies of PAA solutions as a function of pH gave the deprotonation sequence of the triacid. Acidity constants were also determined for phosphonoformic acid, 2-phosphonopropionic acid, and 3-phosphonopropionic acid at an ionic strenght of 0.05. © 1979 Plenum Publishing Corporation.

引用

页码：615 / 625

页数：11

共 16 条

[1]

BOEZI JA, 1979, J PHARM THER, V4, P231

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