HEMATOPOIETIC RECEPTORS AND HELICAL CYTOKINES

被引：602
作者：
BAZAN, JF
机构：
[1] Department of Biochemistry and Biophysics, School of Medicine, University of California, San Francisco
来源：
IMMUNOLOGY TODAY | 1990年 / 11卷 / 10期
关键词：
D O I：
10.1016/0167-5699(90)90139-Z
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A bewitching interplay of proteins, variously clothed as chemical messengers and cellular receptors, control the pace of growth and the course of progressive differentiation in blood cell types1,2. The messengers are lymphokines, interleukins, colony-stimulating factors, growth hormones and interferons: generically, the cytokines. The second components of the regulatory pairs are membrane-spanning receptor proteins: these molecules transduce the specific binding of cognate cytokines into a mitogenic cellular response. In this article, Fernando Bazan discusses a provocative structural model for cytokine-receptor interactions which, if correct, will alter perceptions of the evolutionary design of the haemopoietic system. © 1990.
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收藏
页码：350 / 354
页数：5
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