AUTOXIDATION OF ARACHIDONIC-ACID - FORMATION OF THE PROPOSED SRS-A INTERMEDIATE

被引：135

作者：

PORTER, NA

WOLF, RA

YARBRO, EM

WEENEN, H

机构：

[1] Department of Chemistry, Duke University, Durham

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 89卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0006-291X(79)92115-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The air oxidation of 5,8,11,14-eicosatetraenoic [arachidonic] acid and its methyl ester is reported. A mixture of hydroperoxy arachidonic acid products was obtained from the oxidation and subsequent separation of the mixture by high pressure liquid chromatography led to pure hydroperoxides. One of these hydroperoxides, 5-hydroperoxy-6,8,11,14-eicosatetraenoic acid, is a proposed intermediate in the biosynthesis of slow reacting substance of anaphylaxis. © 1979.

引用

页码：1058 / 1064

页数：7

共 19 条

[1]

BORGEAT P, 1976, J BIOL CHEM, V251, P7816

[2]

BORGEAT P, 1979, J BIOL CHEM, V254, P2643

[3] THERMAL-ISOMERIZATION OF METHYL LINOLEATE HYDROPEROXIDES - EVIDENCE OF MOLECULAR-OXYGEN AS A LEAVING GROUP IN A RADICAL REARRANGEMENT [J].