DIFFERENTIAL-EFFECTS OF ANDROGENS ON CORTICAL BONE HISTOMORPHOMETRY IN GONADECTOMIZED MALE AND FEMALE RATS

被引：172
作者：
TURNER, RT
WAKLEY, GK
HANNON, KS
机构：
[1] MAYO CLIN & MAYO FDN,DEPT ORTHOPED,ROCHESTER,MN 55905
[2] MAYO CLIN & MAYO FDN,DEPT BIOCHEM & MOLEC BIOL,ROCHESTER,MN 55905
[3] MAYO CLIN & MAYO GRAD SCH MED,ROCHESTER,MN 55901
[4] LOMA LINDA UNIV,DEPT ORTHOPED,LOMA LINDA,CA 92350
来源：
JOURNAL OF ORTHOPAEDIC RESEARCH | 1990年 / 8卷 / 04期
关键词：
5α‐Dihydrotestosterone; Bone histomorphometry; Diethylstilbestrol; Fluoxymesterone; Gonadal hormone deficiency; Rat bone; Testosterone;
D O I：
10.1002/jor.1100080418
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
The physiological role of gonadal androgens in regulating bone metabolism is not established. To determine if androgens antagonize the changes in cortical bone after gonadectomy, we treated orchiectomized (ORX) rats with testosterone (T) and 5α‐dihydrotestosterone (DHT), and ovariectomized (OVX) rats with the afore‐mentioned androgens, as well as the synthetic androgen fluoxymesterone (FI) and the nonsteroidal estrogen diethylstilbestrol (DES). OVX resulted in a rapid, sustained increase in periosteal bone formation at the tibial diaphysis, whereas ORX resulted in decreased bone formation. Androgen treatment stimulated bone formation in ORX rats and suppressed bone formation in OVX rats. A large dose of DES suppressed bone formation in OVX rats to values below the intact controls. The results of these studies demonstrate that androgens counteract the changes in cortical bone formation after gonadectomy in females as well as males, and thereby reestablish the sex difference observed in intact rats. Copyright © 1990 Orthopaedic Research Society
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页码：612 / 617
页数：6
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