DIFFERENTIAL CELL-KINETICS IN THE ILEUM AND COLON OF GERM-FREE RATS

被引：88

作者：

ALAM, M

MIDTVEDT, T

URIBE, A

机构：

[1] UNIV UPPSALA HOSP, DEPT MED, S-75185 UPPSALA, SWEDEN

[2] DANDERYD HOSP, DEPT MED, STOCKHOLM, SWEDEN

[3] DANDERYD HOSP, DEPT CLIN PHARMACOL, STOCKHOLM, SWEDEN

[4] KAROLINSKA INST, DEPT MED MICROBIAL ECOL, S-10401 STOCKHOLM, SWEDEN

来源：

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | 1994年 / 29卷 / 05期

关键词：

CELL BIRTH RATE; COLON; GERM-FREE LIFE; GLUCAGON; HYPERPLASIA; MICROFLORA; MITOSIS; RAT SMALL INTESTINE;

D O I：

10.3109/00365529409096836

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Our aim was to study the cell kinetics and epithelial structure in the ileum and colon of conventional and germfree AGUS rats by means of a classic stathmokinetic technique. A slight hyperplasia was observed in the villi of germfree animals (p < 0.05), associated with a comparatively short cell cycle time. The crypt cell production rate was reduced in the colon of germfree rats (p < 0.05), and their crypts contained fewer cells than those of conventional animals (p < 0.05). It is concluded that intraluminal bacteria influence cell proliferation in the colon. The absence of microflora prolongs the cell cycle time and reduces the proliferative activity in the colonic crypts, which contributes to a steady state that is different from that of conventional animals.

引用

页码：445 / 451

页数：7

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