CROSS-REACTIVITY OF OVINE IGE WITH ANTI-HUMAN IGE

被引：1

作者：

YILMAZ, H

MORGAN, KL

ROE, JM

机构：

[1] School of Veterinary Science, Department of Veterinary Medicine, Bristol

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1994年 / 104卷 / 03期

关键词：

IGE; OVINE; HUMAN; CROSS-REACTIVITY;

D O I：

10.1159/000236677

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Cross-reactivity between ovine and human IgE was investigated using monoclonal antibodies to human IgE heavy chain. Western immunoblotting, reverse cutaneous anaphylaxis (RCA), passive cutaneous anaphylaxis inhibition (PCAI) and reverse passive cutaneous anaphylaxis (RPCA) tests were all used to assess cross-reactivity between the monoclonals and ovine IgE. No cross-reactivity was demonstrated using Western immunoblotting, RCA and PCAI tests. However, evidence for homology in the region of the molecule concerned with mast cell binding was demonstrated by RPCA performed in sheep skin primed with human myeloma IgE.

引用

页码：277 / 280

页数：4

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