EFFECTS OF ANTI-INFLAMMATORY STEROIDS ON THE RESPONSE OF THE GUINEA-PIG ISOLATED ILEUM TO ACETYLCHOLINE, HISTAMINE, NICOTINE, 5-HYDROXYTRYPTAMINE AND ELECTRICAL-STIMULATION

被引：9

作者：

FAMAEY, JP ^{[1
]}

FONTAINE, J ^{[1
]}

SEAMAN, I ^{[1
]}

REUSE, J ^{[1
]}

机构：

[1] UNIV BRUSSELS,INST PHARM,B-1000 BRUSSELS,BELGIUM

来源：

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 1979年 / 309卷 / 02期

关键词：

Antiinflammatory steroids; Guinea-pig ileum; Prostaglandins;

D O I：

10.1007/BF00501228

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

High concentrations of antiinflammatory steroids (2.5-40 μg/ml) reversibly inhibited the electrically induced contractions of the guinea-pig isolated ileum. At 40 μg/ml they also reversibly inhibited contractions clicited by acetylcholine, histamine, nicotine and 5-hydroxytryptamine. PGE1 (2.5 ng/ml), PGE2 (2.5 ng/ml) and PGF2α (25 ng/ml) antagonized these effects. The inhibition of contractions elicited by direct agonists were less pronounced than those elicited by indirect or partly indirect agonists. The inhibitory effect of steroids may be related to non-specific actions on biological membranes. An overall sensitization of the smooth muscle by PG's may explain their antagonism to inhibition by steroids. © 1979 Springer-Verlag.

引用

页码：191 / 195

页数：5