MUSCARINIC SUPER-SENSITIVITY - POSSIBLE MODEL FOR THE SLEEP DISTURBANCE OF PRIMARY DEPRESSION

被引：87

作者：

GILLIN, JC

SITARAM, N

DUNCAN, WC

机构：

来源：

PSYCHIATRY RESEARCH | 1979年 / 1卷 / 01期

关键词：

depression; Muscarinic receptors; REM sleep; scopolamine; sleep;

D O I：

10.1016/0165-1781(79)90023-4

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The sleep changes induced in normal volunteers following the administration of scopolamine on 3 consecutive mornings resemble many of the abnormalities observed in the sleep of patients with primary depression: increased sleep latency and reduced rapid eye movement (REM) latency, total sleep time, and sleep efficiency. Furthermore, in a multivariate discriminant analysis-previously shown to distinguish the sleep records of depressed patients from those of normal controls and insomniac patients-the records from baseline nights were selected as normal and those after scopolamine as predominately depressed. Those observations suggest to us that muscarinic supersensitivity in normals may function as a pharmacological model for the sleep disturbances of depression. © 1979.

引用

页码：17 / 22

页数：6

共 19 条

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