PSEUDO-1ST-ORDER ALKALINE-HYDROLYSIS OF DIETHYL TARTRATE - A BASE-LINE STUDY FOR A POLYMER MATRIX USED IN CONTROLLED-RELEASE DELIVERY SYSTEMS

被引：4

作者：

KALONIA, DS ^{[1
]}

SIMONELLI, AP ^{[1
]}

机构：

[1] UNIV CONNECTICUT,INST MAT SCI,STORRS,CT 06269

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1990年 / 79卷 / 04期

关键词：

D O I：

10.1002/jps.2600790420

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The hydrolysis kinetics of a bifunctional group compound, diethyl tartrate, was studied as a function of temperature and pH in the alkaline region. A pH‐stat was used to maintain constant pH conditions in the alkaline region. This allowed the studies to be carried out at low ionic strengths and without the use of buffers. The results indicate that the hydrolysis for both steps followed specific base catalysis. The ratio of the two rate constants was 13.31, which was attributed to a strong charge effect in the second step. The results also show that the use of an overall average rate constant may not be acceptable for multifunctional group compounds. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：364 / 368

页数：5