ABSORPTION OF SERUM ANTI-NUCLEAR ANTIBODIES

被引:2
作者
GELTNER, D
PELED, A
机构
[1] Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot
来源
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1979年 / 13卷 / 03期
关键词
D O I
10.1016/0090-1229(79)90068-0
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The absorption out of antinuclear antibody (ANA) from sera of highly ANA-positive C57BL/6 mice was obtained by different cellular and noncellular factors. A single injection of DNA, liver nuclei, thymocytes, or repeated injections of a soluble material produced by normal mouse splenocytes with (SIRS+) or without (SIRS-) previous stimulation with Con A into ANA-positive mice induced a transient decrease in ANA level, reaching minimal levels at about 14 days after treatment. A similar elimination of ANA was also achieved by in vitro treatment of positive ANA sera from mice or SLE patients with thymocytes, SIRS (+), or SIRS (-). The absorbed ANA could be released by further treatment with DNase, thus indicating that the absorption-out phenomenon involved immune-complex formation. © 1979.
引用
收藏
页码:237 / 245
页数:9
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