COMPLEMENT ACTIVATION DURING SUBSEQUENT STAGES OF CANINE ENDOTOXIN-SHOCK

被引：10
|
作者：
AASEN, AO
MELLBYE, OJ
OHLSSON, K
机构：
[1] MALMO GEN HOSP, DEPT SURG, S-21401 MALMO, SWEDEN
[2] RIKSHOSP OSLO, NATL HOSP NORWAY, INST IMMUNOL & RHEUMATOL, OSLO, NORWAY
来源：
SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1978年 / 8卷 / 06期
关键词：
D O I：
10.1111/j.1365-3083.1978.tb00550.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Changes in total hemolytic complement (C) and levels of C3, C4 and C6 were studied during subsequent stages of lethal [Escherichia coli] endotoxin shock in dogs. Substantial decreases of all parameters were observed. C4 and C6 decreases showed a very similar pattern, indicating activation of C by the classical pathway in addition to the activation of the alternative pathway known to occur in this pathological condition. The role of the C system in the pathophysiology of endotoxin shock are emphasized. C activation has prognostic value during endotoxemia.
引用
收藏
页码：509 / 513
页数：5
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