THE PROSTAGLANDIN RESPONSE IN GUINEA-PIG TAENIA CECI AND TRACHEA SMOOTH-MUSCLE OF DIFFERENT AGES

被引：9
|
作者：
VERMUE, NA [1 ]
DENHERTOG, A [1 ]
机构：
[1] UNIV GRONINGEN, DEPT PHARMACOL CLIN PHARMACOL, BLOEMSINGEL 1, 9713 BZ GRONINGEN, NETHERLANDS
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1988年 / 147卷 / 02期
关键词：
D O I：
10.1016/0014-2999(88)90786-8
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The concentration-response curves for the carbachol-induced contraction of smooth muscle cells of guinea-pig taenia caeci and trachea were not dependent on tissue age. The prostaglandin E2 and F2.alpha. responses increased with age in taenia caeci in contrast with the PGE2 response evoked in trachea. The high-potassium responses evoked in taenia caeci and trachea both increased at higer tissue age. Methoxyverapamil only inhibited the age-dependent responses. The results suggest that it is mainly the voltage-dependent calcium channels that are involved in the age-dependent prostaglandin response.
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页码：273 / 277
页数：5
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