FUNCTIONAL DESENSITIZATION OF THE ISOLATED BETA-ADRENERGIC-RECEPTOR BY THE BETA-ADRENERGIC-RECEPTOR KINASE - POTENTIAL ROLE OF AN ANALOG OF THE RETINAL PROTEIN ARRESTIN (48-KDA PROTEIN)

被引：434
作者：
BENOVIC, JL
KUHN, H
WEYAND, I
CODINA, J
CARON, MG
LEFKOWITZ, RJ
机构：
[1] DUKE UNIV, MED CTR, DEPT BIOCHEM, DURHAM, NC 27710 USA
[2] DUKE UNIV, MED CTR, DEPT PHYSIOL, DURHAM, NC 27710 USA
[3] DUKE UNIV, MED CTR, HOWARD HUGHES MED INST, DURHAM, NC 27710 USA
[4] FORSCHUNGSZENTRUM JULICH, INST BIOL INFORMAT VERARBEITUNG, D-5170 JULICH 1, FED REP GER
[5] BAYLOR COLL MED, DEPT CELL BIOL, HOUSTON, TX 77030 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1987年 / 84卷 / 24期
关键词：
D O I：
10.1073/pnas.84.24.8879
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
引用
收藏
页码：8879 / 8882
页数：4
相关论文
共 22 条
[1]   MOLECULAR-BIOLOGY OF THE VISUAL PIGMENTS [J].
APPLEBURY, ML ;
HARGRAVE, PA .
VISION RESEARCH, 1986, 26 (12) :1881-+
[2]   THE MAMMALIAN BETA-2-ADRENERGIC RECEPTOR - PURIFICATION AND CHARACTERIZATION [J].
BENOVIC, JL ;
SHORR, RGL ;
CARON, MG ;
LEFKOWITZ, RJ .
BIOCHEMISTRY, 1984, 23 (20) :4510-4518
[3]  
BENOVIC JL, 1987, J BIOL CHEM, V262, P9026
[4]   BETA-ADRENERGIC-RECEPTOR KINASE - IDENTIFICATION OF A NOVEL PROTEIN-KINASE THAT PHOSPHORYLATES THE AGONIST-OCCUPIED FORM OF THE RECEPTOR [J].
BENOVIC, JL ;
STRASSER, RH ;
CARON, MG ;
LEFKOWITZ, RJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (09) :2797-2801
[5]   THE MAMMALIAN BETA-2-ADRENERGIC RECEPTOR - RECONSTITUTION OF FUNCTIONAL INTERACTIONS BETWEEN PURE RECEPTOR AND PURE STIMULATORY NUCLEOTIDE BINDING-PROTEIN OF THE ADENYLATE-CYCLASE SYSTEM [J].
CERIONE, RA ;
CODINA, J ;
BENOVIC, JL ;
LEFKOWITZ, RJ ;
BIRNBAUMER, L ;
CARON, MG .
BIOCHEMISTRY, 1984, 23 (20) :4519-4525
[6]   PURE BETA-ADRENERGIC-RECEPTOR - THE SINGLE POLYPEPTIDE CONFERS CATECHOLAMINE RESPONSIVENESS TO ADENYLATE-CYCLASE [J].
CERIONE, RA ;
STRULOVICI, B ;
BENOVIC, JL ;
LEFKOWITZ, RJ ;
CARON, MG .
NATURE, 1983, 306 (5943) :562-566
[7]  
CODINA J, 1984, J BIOL CHEM, V259, P5871
[8]   SIMULTANEOUS ANALYSIS OF FAMILIES OF SIGMOIDAL CURVES - APPLICATION TO BIOASSAY, RADIOLIGAND ASSAY, AND PHYSIOLOGICAL DOSE-RESPONSE CURVES [J].
DELEAN, A ;
MUNSON, PJ ;
RODBARD, D .
AMERICAN JOURNAL OF PHYSIOLOGY, 1978, 235 (02) :E97-E102
[9]   A FAMILY OF RECEPTORS COUPLED TO GUANINE-NUCLEOTIDE REGULATORY PROTEINS [J].
DOHLMAN, HG ;
CARON, MG ;
LEFKOWITZ, RJ .
BIOCHEMISTRY, 1987, 26 (10) :2657-2664
[10]   G-PROTEINS AND DUAL CONTROL OF ADENYLATE-CYCLASE [J].
GILMAN, AG .
CELL, 1984, 36 (03) :577-579
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