ACUTE HYPERPOLARIZATION AND ELONGATION OF COCHLEAR OUTER HAIR-CELLS ON SUPERFUSION WITH CISPLATINUM

被引：0
作者：
ERNST, A [1 ]
ZENNER, HP [1 ]
机构：
[1] UNIV TUBINGEN,DEPT OTOLARYNGOL,TUBINGEN CTR HEARING RES,TUBINGEN,GERMANY
来源：
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY | 1995年 / 252卷 / 03期
关键词：
COCHLEA; OUTER HAIR CELLS; CISPLATINUM OTOTOXICITY; PATCH-CLAMP;
D O I：
暂无
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
The acute effects of cia-platinum on isolated cochlear outer hair cells (OHC) were investigated with whole-cell patch-clamps and measurements of cell length changes. Our findings demonstrated that cis-platinum reversibly induced a hyperpolarization and cellular elongation. These results suggest that the effects produced are the result of an interaction between cia-platinum and transduction channels in OHC. These acute effects are distinctly different from the chronic, irreversible ones that are followed by death of the OHC. The exact mechanism of these chronic effects remains unknown as yet.
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收藏
页码：163 / 166
页数：4
相关论文
共 20 条
[11]   THE OTOTOXIC MECHANISM OF CISPLATIN [J].
MCALPINE, D ;
JOHNSTONE, BM .
HEARING RESEARCH, 1990, 47 (03) :191-204
[12]  
Ohmori H, 1992, Adv Biophys, V28, P1, DOI 10.1016/0065-227X(92)90021-I
[13]   DRUG OTOTOXICITY [J].
RYBAK, LP .
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1986, 26 :79-99
[14]   CISPLATIN NEPHROTOXICITY [J].
SAFIRSTEIN, R ;
WINSTON, J ;
GOLDSTEIN, M ;
MOEL, D ;
DIKMAN, S ;
GUTTENPLAN, J .
AMERICAN JOURNAL OF KIDNEY DISEASES, 1986, 8 (05) :356-367
[15]   A NEWLY IDENTIFIED SURFACE-COAT ON COCHLEAR HAIR-CELLS [J].
SANTI, PA ;
ANDERSON, CB .
HEARING RESEARCH, 1987, 27 (01) :47-65
[16]  
WINER BJ, 1970, STATISTICAL PRINCIPL
[17]   MOTILE RESPONSES IN OUTER HAIR-CELLS [J].
ZENNER, HP .
HEARING RESEARCH, 1986, 22 (1-3) :83-90
[18]  
ZENNER HP, 1993, PROG BRAIN RES, V97, P21
[19]   OUTER HAIR-CELLS AS FAST AND SLOW COCHLEAR AMPLIFIERS WITH A BIDIRECTIONAL TRANSDUCTION CYCLE [J].
ZENNER, HP ;
ARNOLD, W ;
GITTER, AH .
ACTA OTO-LARYNGOLOGICA, 1988, 105 (5-6) :457-462
[20]  
ZENNER HP, 1992, EUR ARCH OTO-RHINO-L, V249, P447
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