ACUTE HYPERPOLARIZATION AND ELONGATION OF COCHLEAR OUTER HAIR-CELLS ON SUPERFUSION WITH CISPLATINUM

被引：0
作者：
ERNST, A [1 ]
ZENNER, HP [1 ]
机构：
[1] UNIV TUBINGEN,DEPT OTOLARYNGOL,TUBINGEN CTR HEARING RES,TUBINGEN,GERMANY
来源：
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY | 1995年 / 252卷 / 03期
关键词：
COCHLEA; OUTER HAIR CELLS; CISPLATINUM OTOTOXICITY; PATCH-CLAMP;
D O I：
暂无
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
The acute effects of cia-platinum on isolated cochlear outer hair cells (OHC) were investigated with whole-cell patch-clamps and measurements of cell length changes. Our findings demonstrated that cis-platinum reversibly induced a hyperpolarization and cellular elongation. These results suggest that the effects produced are the result of an interaction between cia-platinum and transduction channels in OHC. These acute effects are distinctly different from the chronic, irreversible ones that are followed by death of the OHC. The exact mechanism of these chronic effects remains unknown as yet.
引用
收藏
页码：163 / 166
页数：4
相关论文
共 20 条
[1]   EFFECT OF CISPLATIN ON HAIR CELL MORPHOLOGY AND LATERAL WALL NA, K-ATPASE ACTIVITY [J].
BARRON, SE ;
DAIGNEAULT, EA .
HEARING RESEARCH, 1987, 26 (02) :131-137
[2]   EARLY EFFECTS OF GENTAMICIN ON INNER-EAR GLYCOCALYX CYTO-CHEMISTRY [J].
DEGROOT, JCMJ ;
VELDMAN, JE .
HEARING RESEARCH, 1988, 35 (01) :39-45
[3]   REEVALUATION OF INTERACTION OF CIS-DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) WITH DNA [J].
EASTMAN, A .
BIOCHEMISTRY, 1986, 25 (13) :3912-3915
[4]   ACUTE GENTAMICIN OTOTOXICITY IN COCHLEAR OUTER HAIR-CELLS OF THE GUINEA-PIG [J].
ERNST, A ;
REUTER, G ;
ZIMMERMANN, U ;
ZENNER, HP .
BRAIN RESEARCH, 1994, 636 (01) :153-156
[5]  
ERNST A, 1991, EAR BIOL WORSKHOP, P37
[6]  
GITTER AH, 1985, ORL, V48, P68
[7]   INTERACTION OF CISPLATIN AND NOISE ON THE PERIPHERAL AUDITORY-SYSTEM [J].
GRATTON, MA ;
SALVI, RJ ;
KAMEN, BA ;
SAUNDERS, SS .
HEARING RESEARCH, 1990, 50 (1-2) :211-224
[8]   CORRELATIONS BETWEEN CIS-PLATINUM DOSAGE AND TOXICITY IN A GUINEA-PIG MODEL [J].
HOEVE, LJ ;
ZURBORG, IRAMM ;
RODENBURG, M ;
BROCAAR, MP ;
GROEN, BGS .
ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 1988, 245 (02) :98-102
[9]   OTOTOXICITY OF CIS-DICHLORODIAMMINE PLATINUM(II) IN GUINEA-PIGS [J].
KONISHI, T ;
GUPTA, BN ;
PRAZMA, J .
AMERICAN JOURNAL OF OTOLARYNGOLOGY, 1983, 4 (01) :18-26
[10]   THE COMBINED EFFECT OF CISPLATIN AND FUROSEMIDE ON HEARING FUNCTION IN GUINEA-PIGS [J].
LAURELL, G ;
ENGSTROM, B .
HEARING RESEARCH, 1989, 38 (1-2) :19-26
12