PHYSIOPATHOLOGY OF HEMORRHAGIC SYNDROME RELATED TO OCHRATOXIN A INTOXICATION IN RATS

被引:23
作者
GALTIER, P
BONEU, B
CHARPENTEAU, JL
BODIN, G
ALVINERIE, M
MORE, J
机构
[1] ECOLE NATL VET, F-31300 TOULOUSE, FRANCE
[2] INRA, BIOMETRIE LAB, F-31320 Castanet Tolosan, FRANCE
[3] CTR HOSP UNIV PURPAN, HEMOSTASE LAB, F-31300 TOULOUSE, FRANCE
来源
FOOD AND COSMETICS TOXICOLOGY | 1979年 / 17卷 / 01期
关键词
D O I
10.1016/0015-6264(79)90158-5
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Wistar rats were given by gavage a daily 4 mg/kg dose of ochratoxin A over 4, 6, 8 or 10 days. Studies on hemostasis showed a drop in plasma fibrinogen and decreases in factors II, VII and X, and in the thrombocyte and megakaryocyte count. The possibility of a disseminated intravascular coagulation syndrome is discussed. An effective fall in the vitamin-K pool caused ochratoxin A to have an indirect effect similar to that of coumarin. Blood analyses showed a later hemoconcentration related to an increase in neutrophils, which was probably due to the presence of necrotic foci in the organs of the treated animals.
引用
收藏
页码:49 / 53
页数:5
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