IN-VIVO CORRELATES FOR STREPTOCOCCUS-PNEUMONIAE PENICILLIN RESISTANCE IN ACUTE OTITIS-MEDIA

被引：79
作者：
GEHANNO, P
LENOIR, G
BERCHE, P
机构：
[1] HOP NECKER ENFANTS MALAD,MICROBIOL LAB,F-75015 PARIS,FRANCE
[2] HOP NECKER ENFANTS MALAD,DEPT PEDIAT,F-75015 PARIS,FRANCE
[3] HOP BICHAT CLAUDE BERNARD,SERV ORL,PARIS,FRANCE
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 01期
关键词：
D O I：
10.1128/AAC.39.1.271
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Eighty-four children suffering from acute otitis media caused by Streptococcus pneumoniae mere treated prospectively with cefuroxime axetil suspension (30 mg/kg of body weight twice daily for 8 days). The high incidence of isolates with decreased susceptibilities to penicillin (42 of 84 isolates) allowed us to establish a relationship between clinical success and the penicillin MICs for pneumococcal isolates. It was found that cefuroxime axetil is clinically effective in the treatment of acute otitis media caused by penicillin-susceptible and penicillin-intermediate strains of S. pneumoniae. The results indicate that the risk of treatment failure with cefuroxime axetil was increased in children with otitis media caused by S. pneumoniae when the penicillin MIC were greater than or equal to 2 mg/liter.
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页码：271 / 272
页数：2
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