PORCINE PANCREASTATIN HAS NO EFFECT ON ENDOCRINE SECRETION FROM THE PIG PANCREAS

被引：18
|
作者：
HOLST, JJ [1 ]
OSTENSON, CG [1 ]
HARLING, H [1 ]
MESSELL, T [1 ]
机构：
[1] KAROLINSKA HOSP,DEPT ENDOCRINOL,S-10401 STOCKHOLM 60,SWEDEN
来源：
DIABETOLOGIA | 1990年 / 33卷 / 07期
关键词：
chromogranin A; glucagon; Insulin; pancreatic exocrine secretion; perfused pancreas; somatostatin;
D O I：
10.1007/BF00404088
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We investigated the effects of porcine pancreastatin on the endocrine and unstimulated exocrine secretion of isolated, perfused porcine pancreas. Pancreastatin in a concentration of 10-8mol/l had no effect on basal secretion of insulin, glucagon and somatostatin at a perfusate glucose concentration of 5 mmol/l (n=4) and neither at 10-8 nor 10-7 mol/l influenced the hormone responses to acute elevations of perfusate glucose concentration from 3.5 to 11 mmol/l (n=7). This elevation strongly stimulated insulin secretion and inhibited glucagon secretion. Exocrine secretion was not affected by pancreastatin. The results suggest that pancreastatin does not directly influence pancreatic secretion. © 1990 Springer-Verlag.
引用
收藏
页码：403 / 406
页数：4
相关论文
共 50 条
  • [41] Cold-perfusion decellularization of whole-organ porcine pancreas supports human fetal pancreatic cell attachment and expression of endocrine and exocrine markers
    Elebring, Erik
    Kuna, Vijay K.
    Kvarnstroem, Niclas
    Sumitran-Holgersson, Suchitra
    JOURNAL OF TISSUE ENGINEERING, 2017, 8
  • [42] Proghrelin-derived peptides influence the secretion of insulin, glucagon, pancreatic polypeptide and somatostatin:: A study on isolated islets from mouse and rat pancreas
    Qader, Saleem S.
    Hakanson, Rolf
    Rehfeld, Jens F.
    Lundquist, Ingmar
    Salehi, Albert
    REGULATORY PEPTIDES, 2008, 146 (1-3) : 230 - 237
  • [43] Adrenoceptor antagonists, but not guanethidine, reduce glucopenia-induced glucagon secretion from perfused rat pancreas
    Ito, K
    Hirose, H
    Kido, K
    Koyama, K
    Maruyama, H
    Saruta, T
    DIABETES RESEARCH AND CLINICAL PRACTICE, 1995, 30 (03) : 173 - 180
  • [44] The role of islet-1 in the endocrine pancreas Lessons from pancreas specific islet-1 deficient mice
    May, Catherine Lee
    ISLETS, 2010, 2 (02) : 121 - 123
  • [45] EFFECT OF OLEIC-ACID ON INSULIN-SECRETION BY THE ISOLATED PERFUSED RAT PANCREAS
    CAMPILLO, JE
    LUYCKX, AS
    TORRES, MD
    LEFEBVRE, PJ
    DIABETOLOGIA, 1979, 16 (04) : 267 - 273
  • [46] Ghrelin stimulates gastric emptying but is without effect on acid secretion and gastric endocrine cells
    de la Cour, CD
    Lindström, E
    Norlén, P
    Håkanson, RH
    REGULATORY PEPTIDES, 2004, 120 (1-3) : 23 - 32
  • [47] The alpha cell expresses glucagon-like peptide-2 receptors and glucagon-like peptide-2 stimulates glucagon secretion from the rat pancreas
    J. de Heer
    J. Pedersen
    C. Ørskov
    J. J. Holst
    Diabetologia, 2007, 50 : 2135 - 2142
  • [48] The alpha cell expresses glucagon-like peptide-2 receptors and glucagon-like peptide-2 stimulates glucagon secretion from the rat pancreas
    de Heer, J.
    Pedersen, J.
    Orskov, C.
    Holst, J. J.
    DIABETOLOGIA, 2007, 50 (10) : 2135 - 2142
  • [49] Effect of leptin, insulin, and IGF-I on GnRH-induced LH secretion from porcine pituitary cells in vitro
    Kosior-Korzecka, Urszula
    Bobowiec, Ryszard
    BULLETIN OF THE VETERINARY INSTITUTE IN PULAWY, 2007, 51 (03) : 439 - 443
  • [50] Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas
    Kuhre, Rune E.
    Albrechtsen, Nicolai J. Wewer
    Larsen, Olav
    Jepsen, Sara L.
    Balk-Moller, Emilie
    Andersen, Daniel B.
    Deacon, Carolyn F.
    Schoonjans, Kristina
    Reimann, Frank
    Gribble, Fiona M.
    Albrechtsen, Reidar
    Hartmann, Bolette
    Rosenkilde, Mette M.
    Holst, Jens J.
    MOLECULAR METABOLISM, 2018, 11 : 84 - 95
12345