THE COMPLETE DNA-SEQUENCE OF VACCINIA VIRUS

被引：798

作者：

GOEBEL, SJ ^{[1
]}

JOHNSON, GP ^{[1
]}

PERKUS, ME ^{[1
]}

DAVIS, SW ^{[1
]}

WINSLOW, JP ^{[1
]}

PAOLETTI, E ^{[1
]}

机构：

[1] VIROGENET CORP,465 JORDAN RD,RENSSELAER TECHNOL PK,TROY,NY 12180

来源：

VIROLOGY | 1990年 / 179卷 / 01期

关键词：

D O I：

10.1016/0042-6822(90)90294-2

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The complete DNA sequence of the genome of vaccinia virus has been determined. The genome consisted of 191,636 by with a base composition of 66.6% A + T. We have identified 198 "major" protein-coding regions and 65 overlapping "minor" regions, for a total of 263 potential genes. Genes encoded by the virus were located by examination of DNA sequence characteristics and compared with existing vaccinia virus mapping analyses, sequence data, and transcription data. These genes were found to be compactly organized along the genome with relatively few regions of noncoding sequences. Whereas several similarities to proteins of known function were discerned, the function of the majority of proteins encoded by these open reading frames is as yet undetermined. © 1990.

引用

页码：247 / 266

页数：20

共 105 条

[1] IDENTIFICATION OF THE VACCINIA VIRUS GENE ENCODING AN 18-KILODALTON SUBUNIT OF RNA-POLYMERASE AND DEMONSTRATION OF A 5' POLY(A) LEADER ON ITS EARLY TRANSCRIPT [J].

AHN, BY ;

JONES, EV ;

MOSS, B .

JOURNAL OF VIROLOGY, 1990, 64 (06) :3019-3024

[2]

BAIROCH A, 1989, PROSITE DICT PROTEIN

[3] RESISTANCE OF VACCINIA VIRUS TO RIFAMPICIN CONFERRED BY A SINGLE NUCLEOTIDE SUBSTITUTION NEAR THE PREDICTED NH2 TERMINUS OF A GENE ENCODING AN MR 62,000 POLYPEPTIDE [J].

BALDICK, CJ ;

MOSS, B .

VIROLOGY, 1987, 156 (01) :138-145

[4] INCOMPLETELY BASE-PAIRED FLIP-FLOP TERMINAL LOOPS LINK THE 2 DNA STRANDS OF THE VACCINA-VIRUS GENOME INTO ONE UNINTERRUPTED POLYNUCLEOTIDE CHAIN [J].

BAROUDY, BM ;

VENKATESAN, S ;

MOSS, B .

CELL, 1982, 28 (02) :315-324

[5] SEQUENCE HOMOLOGIES OF DIVERSE LENGTH TANDEM REPETITIONS NEAR ENDS OF VACCINIA VIRUS GENOME SUGGEST UNEQUAL CROSSING OVER [J].

BAROUDY, BM ;

MOSS, B .

NUCLEIC ACIDS RESEARCH, 1982, 10 (18) :5673-5679

[6] STRUCTURAL REQUIREMENTS OF N-GLYCOSYLATION OF PROTEINS - STUDIES WITH PROLINE PEPTIDES AS CONFORMATIONAL PROBES [J].

BAUSE, E .

BIOCHEMICAL JOURNAL, 1983, 209 (02) :331-336

[7] VACCINIA VIRUS-19-KILODALTON PROTEIN - RELATIONSHIP TO SEVERAL MAMMALIAN PROTEINS, INCLUDING 2 GROWTH-FACTORS [J].

BLOMQUIST, MC ;

HUNT, LT ;

BARKER, WC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (23) :7363-7367

[8] NON-ESSENTIAL GENES IN THE VACCINIA VIRUS HINDIII K-FRAGMENT - A GENE RELATED TO SERINE PROTEASE INHIBITORS AND A GENE RELATED TO THE K-37 VACCINIA VIRUS MAJOR ENVELOPE ANTIGEN [J].

BOURSNELL, MEG ;

FOULDS, IJ ;

CAMPBELL, JI ;

BINNS, MM .

JOURNAL OF GENERAL VIROLOGY, 1988, 69 :2995-3003

[9] VACCINIA VIRUS ENCODES A POLYPEPTIDE HOMOLOGOUS TO EPIDERMAL GROWTH-FACTOR AND TRANSFORMING GROWTH-FACTOR [J].

BROWN, JP ;

TWARDZIK, DR ;

MARQUARDT, H ;

TODARO, GJ .

NATURE, 1985, 313 (6002) :491-492

[10] IDENTIFICATION OF THE VACCINIA VIRUS GENE ENCODING NUCLEOSIDE TRIPHOSPHATE PHOSPHOHYDROLASE-I, A DNA-DEPENDENT ATPASE [J].

BROYLES, SS ;

MOSS, B .

JOURNAL OF VIROLOGY, 1987, 61 (05) :1738-1742

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