ANTISWEET ACTIVITY OF GYMNEMIC ACID A1 AND ITS DERIVATIVES

被引：84

作者：

KURIHARA, Y

机构：

[1] Department of Biological Science, Florida State University, Tallahassee

来源：

LIFE SCIENCES PART 1 PHYSIOLOGY AND PHARMACOLOGY AND PART 2 BIOCHEMISTRY GENERAL AND MOLECULAR BIOLOGY | 1969年 / 8卷 / 9P1期

关键词：

D O I：

10.1016/0024-3205(69)90449-4

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A method was derived to isolate gymnemic acid A1, a main component of gymnemic acid A, for preparative purpose. Acids esterified in the genin of gymnemic acid A1 were determined to be 1 mole of acetic, 2 moles of isovaleric and 1 mole of tiglic acids. Gymnemic acid A1 was converted into A2, and finally into A3 by alkaline hydrolysis. Antisweet activity of A1 was greatly decreased by conversion into A2, while A3 and had no activity. It is suggested that the ester group in the genin has an important role in the manifestation of the antisweet activity of gymnemic acid A1. Studies regarding antisweet activity of gymnemic acid on other sweet compounds besides sugars indicated that gymnemic acid A1 suppresses the sweet taste of cyclamate, D-amino acids, beryllium chloride, and lead acetate and that it does no suppress the sweet taste of chloroform. © 1969.

引用

页码：537 / &

共 8 条

[1] PAPER-CHROMATOGRAPHIC ANALYSIS OF CARBOXYLIC ACID ESTER MIXTURES AND ITS APPLICATION FOR THE INVESTIGATION OF SYNTHETIC AND NATURAL FLAVOURS - 2ND REPORT ABOUT IRON-(III) HYDROXAMIC ACID COMPLEXES [J].