MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR - ANALYSES OF IN-VITRO EFFECTS ON HUMAN MEGAKARYOPOIESIS AND ENDOGENOUS SERUM LEVELS DURING CHEMOTHERAPY-INDUCED THROMBOCYTOPENIA

被引：187

作者：

NICHOL, JL

HOKOM, MM

HORNKOHL, A

SHERIDAN, WP

OHASHI, H

KATO, T

LI, YS

BARTLEY, TD

CHOI, E

BOGENBERGER, J

SKRINE, JD

KNUDTEN, A

CHEN, J

TRAIL, G

SLEEMAN, L

COLE, S

GRAMPP, G

HUNT, P

机构：

[1] AMGEN INC,AMGEN CTR,THOUSAND OAKS,CA 91320

[2] ROYAL MELBOURNE HOSP,MELBOURNE,VIC 3050,AUSTRALIA

[3] KIRIN BREWERY CO LTD,PHARMACEUT RES LAB,MAEBASHI,GUMMA 371,JAPAN

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1995年 / 95卷 / 06期

关键词：

COLONY FORMING UNIT MEGAKARYOCYTE; THROMBOPOIETIN; PLOIDY; CYTOKINE; PATIENT SERUM;

D O I：

10.1172/JCI118005

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The present study shows that recombinant human megakaryocyte growth and development factor(r-HuMGDF) behaves both as a megakaryocyte colony stimulating factor and as a differentiation factor in human progenitor cell cultures, Megakaryocyte colony formation induced with r-HuMGDF is synergistically affected by stem cell factor but not by interleukin 3. Megakaryocytes stimulated with r-HuMGDF demonstrate progressive cytoplasmic and nuclear maturation, Measurable levels of megakaryocyte growth and development factor in serum from patients undergoing myeloablative therapy and transplantation are shown to be elaborated in response to thrombocytopenic stress. These data support the concept that megakaryocyte growth and development factor is a physiologically regulated cytokine that is capable of supporting several aspects of megakaryopoiesis.

引用

页码：2973 / 2978

页数：6

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