DESIGN AND SYNTHESIS OF A PROTOTYPICAL NONPEPTIDIC INHIBITOR MODEL FOR THE ENZYME RENIN

被引：31

作者：

HANESSIAN, S

RAGHAVAN, S

机构：

[1] Department of Chemistry, Montréal, Que. H3C 3J7, Universite Montreal P.O. Box 6128, Succ. Centre-ville

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(00)80364-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of non-peptidic acyclic and conformationally constrained compounds is described with the intention of designing models and chemical intermediates, for an inhibitor of the enzyme renin.

引用

页码：1697 / 1702

页数：6

共 54 条

[41] THE CRYSTAL-STRUCTURES OF RECOMBINANT GLYCOSYLATED HUMAN RENIN ALONE AND IN COMPLEX WITH A TRANSITION-STATE ANALOG INHIBITOR [J].

RAHUEL, J ;

PRIESTLE, JP ;

GRUTTER, MG .

JOURNAL OF STRUCTURAL BIOLOGY, 1991, 107 (03) :227-236

[42] EFFICIENT TOTAL SYNTHESIS OF (1R,2R,3R,9R,9AR)-1,2,3,9-TETRAHYDROXYQUINOLIZIDINE AND ITS ENANTIOMER [J].

RASSU, G ;

CASIRAGHI, G ;

PINNA, L ;

SPANU, P ;

ULGHERI, F ;

CORNIA, M ;

ZANARDI, F .

TETRAHEDRON, 1993, 49 (30) :6627-6636

[43] A STEREOSELECTIVE SYNTHESIS OF HYDROXYETHYLENE AND ERYTHRO-DIHYDROXYETHYLENE DIPEPTIDE ISOSTERES - A FACIAL SELECTIVE ANTI-ALDOL REACTION [J].

ROSENBERG, SH ;

BOYD, SA ;

MANTEI, RA .

TETRAHEDRON LETTERS, 1991, 32 (45) :6507-6508

[44] AN EFFICIENT SYNTHESIS OF GAMMA-LACTONES AS PRECURSORS OF HYDROXYETHYLENE DIPEPTIDE ISOSTERE [J].

SAKURAI, M ;

SAITO, F ;

OHATA, Y ;

YABE, Y ;

NISHI, T .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1992, (21) :1562-1563

[45] SYNTHESIS OF RENIN INHIBITORS POSSESSING HYDROXYETHYLENE ISOSTERE RESIDUE FROM 3,4,6-TRI-O-ACETYL-D-GLUCAL VIA LACTONE PRECURSOR [J].

SHIOZAKI, M ;

KOBAYASHI, Y ;

HATA, T ;

FURUKAWA, Y .

TETRAHEDRON, 1991, 47 (16-17) :2785-2800

[46] POTENT NEW INHIBITORS OF HUMAN RENIN [J].

SZELKE, M ;

LECKIE, B ;

HALLETT, A ;

JONES, DM ;

SUEIRAS, J ;

ATRASH, B ;

LEVER, AF .

NATURE, 1982, 299 (5883) :555-557

[47]

Szelke M., 1983, PEPTIDES STRUCTURE F, P579

[48]

SZEWCZUK Z, 1992, INT J PEPT PROT RES, V40, P233

[49] THE AMINO TERMINAL AMINO-ACID-SEQUENCE OF HUMAN ANGIOTENSINOGEN [J].

TEWKSBURY, DA ;

DART, RA ;

TRAVIS, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1981, 99 (04) :1311-1315

[50]

WAEBER B, 1986, HDB HYPERTENSION, V8, P489

← 1 2 3 4 5 6 →