DESIGN AND SYNTHESIS OF A PROTOTYPICAL NONPEPTIDIC INHIBITOR MODEL FOR THE ENZYME RENIN

被引：31
作者：
HANESSIAN, S
RAGHAVAN, S
机构：
[1] Department of Chemistry, Montréal, Que. H3C 3J7, Universite Montreal P.O. Box 6128, Succ. Centre-ville
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 14期
关键词：
D O I：
10.1016/S0960-894X(00)80364-9
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of non-peptidic acyclic and conformationally constrained compounds is described with the intention of designing models and chemical intermediates, for an inhibitor of the enzyme renin.
引用
收藏
页码：1697 / 1702
页数：6
相关论文
共 54 条
[1]  
Antonaccio M J, 1987, Prog Drug Res, V31, P161
[2]   DIPEPTIDE ISOSTERES .2. SYNTHESIS OF HYDROXYETHYLENE DIPEPTIDE ISOSTERE DIASTEREOMERS FROM A COMMON GAMMA-LACTONE INTERMEDIATE - PREPARATION OF RENIN AND HIV-1 PROTEASE INHIBITOR TRANSITION-STATE MIMICS [J].
BAKER, WR ;
PRATT, JK .
TETRAHEDRON, 1993, 49 (39) :8739-8756
[3]  
BASHA A, 1977, TETRAHEDRON LETT, P4171
[4]  
BAYLEY H, 1978, TETRAHEDRON LETT, P3633
[5]   RENIN INHIBITORS - SYNTHESES OF SUBNANOMOLAR, COMPETITIVE, TRANSITION-STATE ANALOG INHIBITORS CONTAINING A NOVEL ANALOG OF STATINE [J].
BOGER, J ;
PAYNE, LS ;
PERLOW, DS ;
LOHR, NS ;
POE, M ;
BLAINE, EH ;
ULM, EH ;
SCHORN, TW ;
LAMONT, BI ;
LIN, TY ;
KAWAI, M ;
RICH, DH ;
VEBER, DF .
JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (12) :1779-1790
[6]   RAT ANGIOTENSINOGEN AND DES(ANGIOTENSIN-I)ANGIOTENSINOGEN - PURIFICATION, CHARACTERIZATION, AND PARTIAL SEQUENCING [J].
BOUHNIK, J ;
CLAUSER, E ;
STROSBERG, D ;
FRENOY, JP ;
MENARD, J ;
CORVOL, P .
BIOCHEMISTRY, 1981, 20 (24) :7010-7015
[7]   AN EFFICIENT SYNTHESIS OF THE GAMMA-LACTONE CORRESPONDING TO A HYDROXYETHYLENE DIPEPTIDE ISOSTERE USING STEREOSELECTIVE BROMOLACTONIZATION OF A CHIRAL ACYLOXAZOLIDINONE [J].
BRADBURY, RH ;
REVILL, JM ;
RIVETT, JE ;
WATERSON, D .
TETRAHEDRON LETTERS, 1989, 30 (29) :3845-3848
[8]  
BUHLMAYER P, 1988, J MED CHEM, V31, P1839
[9]  
BULLMAYER P, 1988, J MED CHEM, V31, P1839
[10]   SYNTHESIS OF ENANTIOMERICALLY PURE 2,3-DIDEOXY-HEPT-2-ENONO-1,4-LACTONE DERIVATIVES VIA DIASTEREOSELECTIVE ADDITION OF 2-(TRIMETHYLSILOXY)FURAN TO D-GLYCERALDEHYDE AND D-SERINAL-BASED 3-CARBON SYNTHONS [J].
CASIRAGHI, G ;
COLOMBO, L ;
RASSU, G ;
SPANU, P .
TETRAHEDRON LETTERS, 1989, 30 (39) :5325-5328
123456