STRUCTURE AND FUNCTION OF TELOMERES

被引：3193
作者：
BLACKBURN, EH [1 ]
机构：
[1] DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143
来源：
NATURE | 1991年 / 350卷 / 6319期
关键词：
D O I：
10.1038/350569a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The DNA of telomeres - the terminal DNA-protein complexes of chromosomes - differs notably from other DNA sequences in both structure and function. Recent work has highlighted its remarkable mode of synthesis by the ribonucleoprotein reverse transcriptase, telomerase 1-4, as well as its ability to form unusual structures in vitro. Moreover, telomere synthesis by telomerase has been shown to be essential for telomere maintenance and long-term viability.
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页码：569 / 573
页数：5
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