LIPASE-CATALYZED ENANTIOSELECTIVE HYDROLYSIS OF 4-ALKYL-1,4-DIHYDROPYRIDINE DERIVATIVES - SYNTHESIS OF (+)-METHYL AND (-)-METHYL 2-(PHENYLTHIO)ETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE (PCA 4248)

被引：0

作者：

EBIIKE, H ^{[1
]}

MARUYAMA, K ^{[1
]}

ACHIWA, K ^{[1
]}

机构：

[1] UNIV SHIZUOKA, SCH PHARMACEUT SCI, 52-1 YADA, SHIZUOKA 422, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 04期

关键词：

1,4-DIHYDROPYRIDINE; LIPASE; ENANTIOSELECTIVE HYDROLYSIS; ACYLOXYMETHYL ESTER; PAF ANTAGONIST;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Asymmetric synthesis of (+)- and (-)-PCA 4248 (PAF antagonist) was achieved using lipase-catalyzed enantioselective hydrolysis of the acyloxymethyl esters. The enzymatic reaction proceeded under the mild conditions in an organic solvent.

引用

页码：1083 / 1085

页数：3

共 17 条

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