THE APOLIPOPROTEIN-E ALLELE EPSILON-4 IS OVERREPRESENTED IN PATIENTS WITH THE LEWY BODY VARIANT OF ALZHEIMERS-DISEASE

被引：135

作者：

GALASKO, D ^{[1
]}

SAITOH, T ^{[1
]}

XIA, Y ^{[1
]}

THAL, LJ ^{[1
]}

KATZMAN, R ^{[1
]}

HILL, LR ^{[1
]}

HANSEN, L ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,DEPT NEUROSCI,SAN DIEGO,CA

来源：

NEUROLOGY | 1994年 / 44卷 / 10期

关键词：

D O I：

10.1212/WNL.44.10.1950

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We determined apolipoprotein E (ApoE) genotypes in 122 autopsied demented patients. The frequency of the ApoE epsilon 4 allele was 39.6% in Alzheimer's disease (AD), 29.0% in the Lewy body variant of AD (LBV), and 6.25% in diffuse Lewy body disease. For AD and LBV patients, the epsilon 4 frequency was significantly higher than that reported in nondemented controls (10 to 15%). Therefore, LBV and AD share ApoE epsilon 4 as a genetic risk factor, providing further evidence that these conditions overlap.

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页码：1950 / 1951

页数：2

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