ALLOGENEIC MARROW TRANSPLANTATION FOR ACUTE-LEUKEMIA IN RELAPSE

被引：68

作者：

BADGER, C ^{[1
]}

BUCKNER, CD ^{[1
]}

THOMAS, ED ^{[1
]}

CLIFT, RA ^{[1
]}

SANDERS, JE ^{[1
]}

STEWART, PS ^{[1
]}

STORB, R ^{[1
]}

SULLIVAN, KM ^{[1
]}

SHULMAN, H ^{[1
]}

FLOURNOY, N ^{[1
]}

机构：

[1] UNIV WASHINGTON, SCH MED, SEATTLE, WA 98195 USA

来源：

LEUKEMIA RESEARCH | 1982年 / 6卷 / 03期

关键词：

D O I：

10.1016/0145-2126(82)90101-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The results of allogeneic marrow transplantation in 75 patients with acute lymphoblastic leukemia and 63 patients with acute non-lymphoblastic leukemia in relapse are reviewed. The effects of various chemotherapeutic regimens added to the basic regimen of cyclophosphamide (Cy) 60 mg/kg given on each of 2 successive days followed by 1000 rad of total body irradiation (TBI) were evaluated. The regimens tested were dimethylbusulphan (DMB), 1,3-(bis(2-chlorethyl)-1-nitrosourea (BCNU) and daunorubicin. Seventeen of 138 patients are alive between 3 and 9.5 yr from transplantation. The addition of other chemotherapeutic agents to the basic Cy and TBI regimen did not decrease relapse frequency or prolong survival.

引用

页码：383 / 387

页数：5

共 17 条

[1]

CAMITTA BM, 1979, BLOOD, V53, P504

[2]

GALE RP, 1980, BIOL BONE MARROW TRA, P11

[3] RELAPSE FOLLOWING MARROW TRANSPLANTATION FOR ACUTE-LEUKEMIA [J].

HARRISON, DT ;

FLOURNOY, N ;

RAMBERG, R ;

BOYD, C ;

ERNE, K ;

BUCKNER, CD ;

FEFER, A ;

SANDERS, JE ;

STORB, R ;

THOMAS, ED .

AMERICAN JOURNAL OF HEMATOLOGY, 1978, 5 (03) :191-202

[4] NONPARAMETRIC-ESTIMATION FROM INCOMPLETE OBSERVATIONS [J].

KAPLAN, EL ;

MEIER, P .

JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1958, 53 (282) :457-481

[5] UNIFORMITY AND STANDARDIZATION OF SINGLE AND OPPOSING COBALT 60 SOURCES FOR TOTAL-BODY IRRADIATION [J].

LAM, WC ;

ORDER, SE ;

THOMAS, ED .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1980, 6 (02) :245-250

[6]

STEWART PS, 1979, EXP HEMATOL, V7, P509

[7] MARROW TRANSPLANTATION FOR ACUTE NONLYMPHOBLASTIC LEUKEMIA IN 1ST REMISSION [J].

THOMAS, ED ;

BUCKNER, CD ;

CLIFT, RA ;

FEFER, A ;

JOHNSON, FL ;

NEIMAN, PE ;

SALE, GE ;

SANDERS, JE ;

SINGER, JW ;

SHULMAN, H ;

STORB, R ;

WEIDEN, PL .

NEW ENGLAND JOURNAL OF MEDICINE, 1979, 301 (11) :597-599

[8] TECHNIQUE FOR HUMAN MARROW GRAFTING [J].

THOMAS, ED ;

STORB, R .

BLOOD-THE JOURNAL OF HEMATOLOGY, 1970, 36 (04) :507-&

[9] BONE-MARROW TRANSPLANTATION .1. [J].

THOMAS, ED ;

STORB, R ;

CLIFT, RA ;

FEFER, A ;

JOHNSON, FL ;

NEIMAN, PE ;

LERNER, KG ;

GLUCKSBERG, H ;

BUCKNER, CD .

NEW ENGLAND JOURNAL OF MEDICINE, 1975, 292 (16) :832-843

[10] ALLOGENEIC MARROW GRAFTING FOR HEMATOLOGIC MALIGNANCY USING HL-A MATCHED DONOR-RECIPIENT SIBLING PAIRS [J].

THOMAS, ED ;

BUCKNER, CD ;

RUDOLPH, RH ;

FEFER, A ;

STORB, R ;

NEIMAN, PE ;

BRYANT, JI ;

CHARD, RL ;

CLIFT, RA ;

EPSTEIN, RB ;

FIALKOW, PJ ;

FUNK, DD ;

GIBLETT, ER ;

LERNER, KG ;

REYNOLDS, FA ;

SLICHTER, S .

BLOOD-THE JOURNAL OF HEMATOLOGY, 1971, 38 (03) :267-&

← 1 2 →