HETEROGENEITY OF RENIN ALLELES IN OUTBRED DAHL SALT-SENSITIVE (BROOKHAVEN) RATS

被引：14
作者：
ODOWD, BF
RAPP, JP
机构：
[1] MED COLL OHIO,DEPT MED,CS 10008,TOLEDO,OH 43699
[2] UNIV TORONTO,DEPT PHARMACOL,TORONTO M5S 1A1,ONTARIO,CANADA
[3] MED COLL OHIO,DEPT PATHOL,TOLEDO,OH 43699
[4] ADDICT RES FDN,TORONTO M5S 2S1,ONTARIO,CANADA
来源：
HYPERTENSION | 1991年 / 18卷 / 01期
关键词：
SALT-SENSITIVE HYPERTENSION; RENIN; DNA FINGERPRINTING GENETICS; DAHL RATS;
D O I：
10.1161/01.HYP.18.1.9
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Selectively outbred Dahl salt-sensitive (DS) and salt-resistant (DR) rats were compared with the inbred Dahl salt-sensitive (SS/Jr) and salt-resistant (SR/Jr) rats developed from the original Brookhaven stocks by J.P. Rapp. The animals were evaluated for genotype at the renin locus. The inbred strains are uniformly homozygous for their respective alleles, s in SS/Jr and r in SR/Jr. DR rats were also uniformly homozygous for the r renin allele. In DS rats, however, three renin alleles were segregating. In addition to the s and r alleles, a third allele, designated the z allele, was found. The gene frequencies in DS rats were s = 0.690, r = 0.284, and z = 0.026. Continued use of DS and DR rats in most experimental work is inappropriate because of genetic heterogeneity in the DS stock.
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页码：9 / 11
页数：3
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