REGULATION OF THE NMDA RECEPTOR BY REDOX PHENOMENA - INHIBITORY ROLE OF ASCORBATE

被引:157
作者
MAJEWSKA, MD
BELL, JA
LONDON, ED
机构
[1] Neuropharmacology Laboratory, Neuroscience Branch, Addiction Research Center, Baltimore
关键词
N-METHYL-D-ASPARTATE RECEPTOR; REDOX; ASCORBIC ACID;
D O I
10.1016/0006-8993(90)90379-P
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Redox phenomena seem to modulate activity of the N-methyl-D-aspartate receptor. Some reductants (ascorbate, hydroquinone) inhibit, while others (dithiothreitol, mercaptoethanol, penicillamine) potentiate NMDA receptor function. Ascorbate inhibits binding of [H-3]glutamate and [H-3]thienylcyclohexylpiperidine to the NMDA receptor complex, and impedes NMDA-gated currents in isolated neurons; dithiothreitol-like reductants enhance NMDA-induced currents. The ability of reductants to alter functions of the NMDA receptor is abolished by oxidation.
引用
收藏
页码:328 / 332
页数:5
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