REGULATION OF THE NMDA RECEPTOR BY REDOX PHENOMENA - INHIBITORY ROLE OF ASCORBATE

被引：159

作者：

MAJEWSKA, MD

BELL, JA

LONDON, ED

机构：

[1] Neuropharmacology Laboratory, Neuroscience Branch, Addiction Research Center, Baltimore

来源：

BRAIN RESEARCH | 1990年 / 537卷 / 1-2期

关键词：

N-METHYL-D-ASPARTATE RECEPTOR; REDOX; ASCORBIC ACID;

D O I：

10.1016/0006-8993(90)90379-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Redox phenomena seem to modulate activity of the N-methyl-D-aspartate receptor. Some reductants (ascorbate, hydroquinone) inhibit, while others (dithiothreitol, mercaptoethanol, penicillamine) potentiate NMDA receptor function. Ascorbate inhibits binding of [H-3]glutamate and [H-3]thienylcyclohexylpiperidine to the NMDA receptor complex, and impedes NMDA-gated currents in isolated neurons; dithiothreitol-like reductants enhance NMDA-induced currents. The ability of reductants to alter functions of the NMDA receptor is abolished by oxidation.

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页码：328 / 332

页数：5

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