REGULATION OF THE NMDA RECEPTOR BY REDOX PHENOMENA - INHIBITORY ROLE OF ASCORBATE

被引：157
作者：
MAJEWSKA, MD
BELL, JA
LONDON, ED
机构：
[1] Neuropharmacology Laboratory, Neuroscience Branch, Addiction Research Center, Baltimore
来源：
BRAIN RESEARCH | 1990年 / 537卷 / 1-2期
关键词：
N-METHYL-D-ASPARTATE RECEPTOR; REDOX; ASCORBIC ACID;
D O I：
10.1016/0006-8993(90)90379-P
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Redox phenomena seem to modulate activity of the N-methyl-D-aspartate receptor. Some reductants (ascorbate, hydroquinone) inhibit, while others (dithiothreitol, mercaptoethanol, penicillamine) potentiate NMDA receptor function. Ascorbate inhibits binding of [H-3]glutamate and [H-3]thienylcyclohexylpiperidine to the NMDA receptor complex, and impedes NMDA-gated currents in isolated neurons; dithiothreitol-like reductants enhance NMDA-induced currents. The ability of reductants to alter functions of the NMDA receptor is abolished by oxidation.
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页码：328 / 332
页数：5
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