Building blocks for the synthesis of post-translationally modified glycated peptides and proteins

被引：14

作者：

Carganico, Stefano ^{[2
,3
]}

Rovero, Paolo ^{[2
,4
]}

Halperin, Jose A. ^{[1
,5
]}

Papini, Anna Maria ^{[2
,3
]}

Chorev, Michael ^{[1
,5
]}

机构：

[1] Harvard Univ, Sch Med, Lab Translat Res, Cambridge, MA 02139 USA

[2] Univ Florence, Lab Peptide & Prot Chem & Biol, I-50019 Sesto Fiorentino, Italy

[3] Univ Florence, Dipartimento Chim Organ, I-50019 Sesto Fiorentino, Italy

[4] Univ Florence, Dipartimento Sci Farmaceut, I-50019 Sesto Fiorentino, Italy

[5] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

来源：

JOURNAL OF PEPTIDE SCIENCE | 2009年 / 15卷 / 02期

关键词：

glycation; Amadori rearrangement; Lys(N-epsilon-1-deoxyfructopyranosyl); Amadori-containing building block; site-specific modification; SPPS; MAILLARD REACTION; END-PRODUCTS; SOLID-PHASE; D-FRUCTOSE; AMADORI; GLUCOSE; DISEASE; STRESS;

D O I：

10.1002/psc.1105

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Growing interest in synthetic peptides carrying post-traslational modifications, in general, and the Amadori modification in particular, raises the need for specific building blocks that can be used in stepwise peptide synthesis. Herein, we report the synthesis of N-alpha-Fmoc-Lys-OH derivatives containing N-epsilon-1-deoxyfructopyranosyl moiety. Copyright (c) 2008 European Peptide Society and John Wiley & Sons, Ltd.

引用

页码：67 / 71

页数：5

共 22 条

[1] Molecular basis for a link between complement and the vascular complications of diabetes [J].