AGE MODULATES EFFECTS OF THYROID-DYSFUNCTION ON SEX-HORMONE BINDING GLOBULIN (SHBG) LEVELS

被引：8
作者：
LECOMTE, P
LECUREUIL, N
LECUREUIL, M
SALAZAR, CO
VALAT, C
机构：
[1] UFR PHARM,BIOPHYS & BIOMATH LAB,F-37200 TOURS,FRANCE
[2] CHR UNIV BRETONNEAU,TOURS,FRANCE
来源：
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES | 1995年 / 103卷 / 05期
关键词：
AGING; SHBG; THYROID DYSFUNCTION; HYPOTHYROIDISM; HYPERTHYROIDISM;
D O I：
10.1055/s-0029-1211375
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Symptoms of thyroid dysfunction are difficult to detect in elderly people and TSH is sometimes unreliable. We therefore tested the value of SHBG as a marker of thyroid hormone action on the liver to determine the thyroid status of elderly people. Aging euthyroid men and women have a significant increase in SHBG (p > 0.0001). In aging women the decrease in SHBG with hypothyroidism and increase with hyperthyroidism are highly significant (p < 0.0001 and p < 0.0005 respectively). No significant variation in SHBG was observed in men with thyroid dysfunction. SHBG can help to determine the thyroid status of aging women.
引用
收藏
页码：339 / 342
页数：4
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