AGE MODULATES EFFECTS OF THYROID-DYSFUNCTION ON SEX-HORMONE BINDING GLOBULIN (SHBG) LEVELS

被引：8
|
作者：
LECOMTE, P
LECUREUIL, N
LECUREUIL, M
SALAZAR, CO
VALAT, C
机构：
[1] UFR PHARM,BIOPHYS & BIOMATH LAB,F-37200 TOURS,FRANCE
[2] CHR UNIV BRETONNEAU,TOURS,FRANCE
来源：
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES | 1995年 / 103卷 / 05期
关键词：
AGING; SHBG; THYROID DYSFUNCTION; HYPOTHYROIDISM; HYPERTHYROIDISM;
D O I：
10.1055/s-0029-1211375
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Symptoms of thyroid dysfunction are difficult to detect in elderly people and TSH is sometimes unreliable. We therefore tested the value of SHBG as a marker of thyroid hormone action on the liver to determine the thyroid status of elderly people. Aging euthyroid men and women have a significant increase in SHBG (p > 0.0001). In aging women the decrease in SHBG with hypothyroidism and increase with hyperthyroidism are highly significant (p < 0.0001 and p < 0.0005 respectively). No significant variation in SHBG was observed in men with thyroid dysfunction. SHBG can help to determine the thyroid status of aging women.
引用
收藏
页码：339 / 342
页数：4
相关论文
共 50 条
  • [1] Sex Hormone-Binding Globulin (SHBG), estradiol and breast cancer
    Fortunati, N.
    Catalano, M. G.
    Boccuzzi, G.
    Frairia, R.
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2010, 316 (01) : 86 - 92
  • [2] Sex hormone binding globulin (SHBG) modulates mitochondrial dynamics in PPARγ-depleted equine adipose derived stromal cells
    Marycz, Krzysztof
    Wiatrak, Benita
    Irwin-Houston, Jennifer M.
    Marcinkowska, Klaudia
    Mularczyk, Malwina
    Bourebaba, Lynda
    JOURNAL OF MOLECULAR MEDICINE-JMM, 2024, 102 (08): : 1015 - 1036
  • [3] Elevated sex-hormone binding globulin in elderly women with Alzheimer's disease
    Hoskin, EK
    Tang, MX
    Manly, JJ
    Mayeux, R
    NEUROBIOLOGY OF AGING, 2004, 25 (02) : 141 - 147
  • [4] Steroid-binding characteristics of sex hormone-binding globulin (SHBG) in carp, Cyprinus carpio
    Okunaga, M
    Matsubara, T
    Ohkubo, N
    Nagae, M
    FISH PHYSIOLOGY AND BIOCHEMISTRY, 2003, 28 (1-4) : 219 - 220
  • [5] Steroid-binding characteristics of sex hormone-binding globulin (SHBG) in carp, Cyprinus carpio
    M. Okunaga
    T. Matsubara
    N. Ohkubo
    M. Nagae
    Fish Physiology and Biochemistry, 2003, 28 : 219 - 220
  • [6] Identification of a novel Sex Hormone Binding Globulin (SHBG) in the rainbow trout (Oncorhynchys mykiss) ovary
    Bobe, Julien
    Mahe, Sophie
    Nguyen, Thaovi
    Rime, Helene
    Vizziano, Denise
    Fostier, Alexis
    Guiguen, Yann
    CYBIUM, 2008, 32 (02): : 151 - 152
  • [7] Sex hormone-binding globulin (SHBG) is a potential early diagnostic biomarker for gastric cancer
    Cheng, Chao-Wen
    Chang, Che-Chang
    Patria, Yudha Nur
    Chang, Ruei-Ting
    Liu, Yun-Ru
    Li, Fu-An
    Shih, Hsiu-Ming
    Lin, Ching-Yu
    CANCER MEDICINE, 2018, 7 (01): : 64 - 74
  • [8] Sex Hormone Binding Globulin (SHBG) Mitigates ER Stress in Hepatocytes In Vitro and Ex Vivo
    Kornicka-Garbowska, Katarzyna
    Bourebaba, Lynda
    Roecken, Michael
    Marycz, Krzysztof
    CELLS, 2021, 10 (04)
  • [9] Specific binding of exogenous sex hormones and chemical substances to sex hormone-binding globulin (SHBG) in carp and rainbow trout
    Nagae, Masaki
    Suminami, Yuichi
    Kitagawa, Hiroko
    Shiroyama, Ken'ichirou
    Ohkubo, Nobuyuki
    Matsubara, Takahiro
    CYBIUM, 2008, 32 (02): : 244 - 244
  • [10] Sex hormone-binding globulin (SHBG) and estradiol cross-talk in breast cancer cells
    Fortunati, N
    Catalan, MG
    HORMONE AND METABOLIC RESEARCH, 2006, 38 (04) : 236 - 240
12345