5-HYDROXYTRYPTAMINE INCREASES SPONTANEOUS ACTIVITY OF SUBTHALAMIC NEURONS IN THE RAT

被引：39

作者：

FLORES, G ^{[1
]}

RESALES, MG ^{[1
]}

HERNANDEZ, S ^{[1
]}

SIERRA, A ^{[1
]}

ACEVES, J ^{[1
]}

机构：

[1] INST POLITECN NACL,CTR INVEST & ESTUDIOS AVANZADOS,DEPT FISIOL BIOFIS & NEUROSCI,MEXICO CITY 07000,DF,MEXICO

来源：

NEUROSCIENCE LETTERS | 1995年 / 192卷 / 01期

关键词：

BASAL GANGLIA; SUBTHALAMIC NUCLEUS; SEROTONIN; SEROTONINERGIC ACTION; MIANSERIN;

D O I：

10.1016/0304-3940(95)11597-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of 5-hydroxytryptamine on the spontaneous activity of neurons of the subthalamic nucleus was examined by recording the extracellular unitary activity in an in vitro slice preparation. The most frequent response to 5-hydroxytryptamine (84% of 57 neurons tested) was an increase (twofold of basal at 10 mu M) of the discharge frequency. The EC(50) for the 5-hydroxytryptamine-induced effect was 1.8 +/- 0.5 mu M (mean +/- SEM). The response was dose-dependently blocked by the serotoninergic antagonist mianserin and was not prevented by removal of calcium ions from the perfusing buffer. These results indicate that the serotoninergic input to the rat subthalamic nucleus exerts a postsynaptic excitatory action on most neurons of the nucleus.

引用

页码：17 / 20

页数：4

共 22 条

[1] INTRACELLULAR STUDIES IN THE FACIAL NUCLEUS ILLUSTRATING A SIMPLE NEW METHOD FOR OBTAINING VIABLE MOTONEURONS IN ADULT-RAT BRAIN-SLICES [J].