DEPRESSIVE AND EXTRAPYRAMIDAL SYMPTOMS AND CLINICAL EFFECTS - TRIAL OF FLUPHENAZINE VERSUS FLUPENTHIXOL IN MAINTENANCE OF SCHIZOPHRENIC OUT-PATIENTS

被引:61
作者
KNIGHTS, A [1 ]
OKASHA, MS [1 ]
ALISALIH, M [1 ]
HIRSCH, SR [1 ]
机构
[1] YALE UNIV,SCH MED,NEW HAVEN,CT 06520
关键词
D O I
10.1192/bjp.135.6.515
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Fifty-seven patients with a diagnosis of schizophrenia were started on either fluphenazine decanoate or fluphenthixol decanoate injections in a double-blind trial just prior to discharge into the community. During the six month follow-up 30% dropped out of the treatment. Of those observed for 6 months, 7% relapsed, 54% experienced depressive symptoms and 88% extrapyramidal side-effects. Analysis of both clinical data and the ratings failed to discriminate between the two drugs.
引用
收藏
页码:515 / 523
页数:9
相关论文
共 19 条
[1]  
ALARCON RD, 1969, BRIT MED J, V3, P564
[2]  
Carney M W, 1973, Curr Med Res Opin, V1, P423, DOI 10.1185/03007997309111704
[3]   ANTIPARKINSONIAN AGENTS AND DEPOT PHENOTHIAZINE [J].
CHIEN, CP ;
DIMASCIO, A ;
COLE, JO .
AMERICAN JOURNAL OF PSYCHIATRY, 1974, 131 (01) :86-90
[4]   FLUPENTHIXOL IN TREATMENT OF SCHIZOPHRENIA [J].
HALL, P ;
COLEMAN, J .
BRITISH JOURNAL OF PSYCHIATRY, 1972, 120 (555) :241-&
[5]   COMPARATIVE TRIAL OF FLUPHENAZINE DECANOATE AND FLUPENTHIXOL DECANOATE [J].
HASLAM, MT ;
BROMHAM, BM ;
SCHIFF, AA .
ACTA PSYCHIATRICA SCANDINAVICA, 1975, 51 (02) :92-100
[6]   OUTPATIENT MAINTENANCE OF CHRONIC SCHIZOPHRENIC PATIENTS WITH LONG-ACTING FLUPHENAZINE - DOUBLE-BLIND PLACEBO TRIAL - REPORT TO MEDICAL-RESEARCH COUNCIL COMMITTEE ON CLINICAL TRIALS IN PSYCHIATRY [J].
HIRSCH, SR ;
GAIND, R ;
ROHDE, PD ;
STEVENS, BC ;
WING, JK .
BRITISH MEDICAL JOURNAL, 1973, 1 (5854) :633-637
[7]   DRUG DEFAULTING BY PATIENTS ON LONG-ACTING PHENOTHIAZINES [J].
JOHNSON, DAW ;
FREEMAN, H .
PSYCHOLOGICAL MEDICINE, 1973, 3 (01) :115-119
[8]   SIDE-EFFECTS OF FLUPHENAZINE DECANOATE [J].
JOHNSON, DAW .
BRITISH JOURNAL OF PSYCHIATRY, 1973, 123 (576) :519-522
[9]   DOUBLE-BLIND COMPARISON OF FLUPHENAZINE DECANOATE AND FLUPENTHIXOL DECANOATE IN TREATMENT OF ACUTE SCHIZOPHRENIA [J].
JOHNSON, DAW ;
MALIK, NA .
ACTA PSYCHIATRICA SCANDINAVICA, 1975, 51 (04) :257-267
[10]  
KELLY HB, 1977, INT PHARMACOPSYCHIAT, V12, P56