EXERCISE TRAINING INCREASES GLUCOSE TRANSPORTER PROTEIN GLUT-4 IN SKELETAL-MUSCLE OF OBESE ZUCKER (FA/FA) RATS

被引：149

作者：

FRIEDMAN, JE ^{[1
]}

SHERMAN, WM ^{[1
]}

REED, MJ ^{[1
]}

ELTON, CW ^{[1
]}

DOHM, GL ^{[1
]}

机构：

[1] OHIO STATE UNIV,SCH HLTH PHYS EDUC & RECREAT,COLUMBUS,OH 43210

来源：

FEBS LETTERS | 1990年 / 268卷 / 01期

关键词：

Exercise; Glucose transporter; Insulin resistance; Obesity; Skeletal muscle;

D O I：

10.1016/0014-5793(90)80960-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present study examined the level of GLUT-4 glucose transporter protein in gastrocnemius muscles of 36 week old genetically obese Zucker (fa/fa) rats and their lean (Fa/-) littermates, and in obese Zucker rats following 18 or 30 weeks of treadmill exercise training. Despite skeletal muscle insulin resistance, the level of GLUT-4 glucose transporter protein was similar in lean and obese Zucker rats. In contrast, exercise training increased GLUT-4 protein levels by 1.7 and 2.3 fold above sedentary obese rats. These findings suggest endurance training stimulates expression of skeletal muscle GLUT-4 protein which may be responsible for the previously observed increase in insulin sensitivity with training. © 1990.

引用

页码：13 / 16

页数：4

共 50 条

[21] Exercise training and the glucose transport system in obese SHHF/Mcc-fa(cp) rats [J].

Ferrara, CM ;

Sherman, WM ;

Leenders, N ;

McCune, SA ;

Roehrig, K .

JOURNAL OF APPLIED PHYSIOLOGY, 1996, 81 (04) :1670-1676

[22] IMPAIRED GLUCOSE-TRANSPORT IN SKELETAL-MUSCLE BUT NORMAL GLUT-4 TISSUE DISTRIBUTION IN GLUCOSE-INFUSED RATS [J].

DAVIDSON, MB ;

BOUCH, C ;

VENKATESAN, N ;

KARJALA, RG .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1994, 267 (06) :E808-E813

[23] Selective resistance to vasoactive effects of insulin in muscle resistance arteries of obese Zucker (fa/fa) rats [J].

Eringa, Etto C. ;

Stehouwer, Coen D. A. ;

Roos, Marjon H. ;

Westerhof, Nico ;

Sipkema, Pieter .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2007, 293 (05) :E1134-E1139

[24] Processing Alaska Pollock Protein (Theragra chalcogramma) into Kamaboko Protein Mitigates Elevated Serum Cholesterol and Postprandial Glucose Levels in Obese Zucker fa/fa Rats [J].

Takada, Natsuka ;

Hosomi, Ryota ;

Fukunaga, Kenji .

FOODS, 2022, 11 (21)

[25] DEPLETION OF ADIPOCYTE GLUCOSE TRANSPORTERS (GLUT-4) BUT NORMAL SKELETAL-MUSCLE GLUT-4 EXPRESSION IN THE INSULIN-RESISTANT HIGH-FAT FED RAT [J].

FRYER, LG ;

BALDWIN, SA ;

KRUSZYNSKA, YT .

DIABETES NUTRITION & METABOLISM, 1993, 6 (05) :241-250

[26] Effects of feeding acarbose on muscle glucose transport and GLUT4 protein in lean and obese diabetic (ZDF/Gmi-fa) rats [J].

Dolan, PL ;

Tapscott, EB ;

Peterson, RG ;

Dohm, GL .

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 1997, 8 (06) :322-327

[27] Modulation by glucose of insulin secretion and glucose phosphorylating activity in cultured pancreatic islets from obese (fa/fa) Zucker rats [J].

Chan, CB ;

Lowe, J ;

Debertin, W .

INTERNATIONAL JOURNAL OF OBESITY, 1996, 20 (02) :175-184

[28] Changes of islet size and islet size distribution resulting from protein-malnutrition in lean (Fa/Fa) and obese (fa/fa) Zucker rats [J].

Tse, EO ;

Gregoire, FM ;

Reusens, B ;

Remacle, C ;

Hoet, JJ ;

Johnson, PR ;

Stern, JS .

OBESITY RESEARCH, 1997, 5 (06) :563-571

[29] Subdiaphragmatic vagal deafferentation affects body weight gain and glucose metabolism in obese male Zucker (fa/fa) rats [J].

Ferrari, B ;

Arnold, M ;

Carr, RD ;

Langhans, W ;

Pacini, G ;

Bodvarsdóttir, TB ;

Gram, DX .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2005, 289 (04) :R1027-R1034

[30] INSULIN-RECEPTOR AND GLUCOSE TRANSPORTER MESSENGER-RNA EXPRESSION IN SKELETAL-MUSCLE OF GENETICALLY-OBESE ZUCKER RATS [J].

KNOTT, RM ;

HESKETH, JE .

FEBS LETTERS, 1992, 309 (02) :153-156

← 1 2 3 4 5 →