EXERCISE TRAINING INCREASES GLUCOSE TRANSPORTER PROTEIN GLUT-4 IN SKELETAL-MUSCLE OF OBESE ZUCKER (FA/FA) RATS

被引：149

作者：

FRIEDMAN, JE ^{[1
]}

SHERMAN, WM ^{[1
]}

REED, MJ ^{[1
]}

ELTON, CW ^{[1
]}

DOHM, GL ^{[1
]}

机构：

[1] OHIO STATE UNIV,SCH HLTH PHYS EDUC & RECREAT,COLUMBUS,OH 43210

来源：

FEBS LETTERS | 1990年 / 268卷 / 01期

关键词：

Exercise; Glucose transporter; Insulin resistance; Obesity; Skeletal muscle;

D O I：

10.1016/0014-5793(90)80960-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present study examined the level of GLUT-4 glucose transporter protein in gastrocnemius muscles of 36 week old genetically obese Zucker (fa/fa) rats and their lean (Fa/-) littermates, and in obese Zucker rats following 18 or 30 weeks of treadmill exercise training. Despite skeletal muscle insulin resistance, the level of GLUT-4 glucose transporter protein was similar in lean and obese Zucker rats. In contrast, exercise training increased GLUT-4 protein levels by 1.7 and 2.3 fold above sedentary obese rats. These findings suggest endurance training stimulates expression of skeletal muscle GLUT-4 protein which may be responsible for the previously observed increase in insulin sensitivity with training. © 1990.

引用

页码：13 / 16

页数：4

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