MEASUREMENT OF PARTITION-COEFFICIENTS BY VARIOUS CENTRIFUGAL PARTITION CHROMATOGRAPHIC TECHNIQUES - A COMPARATIVE-EVALUATION

被引：57

作者：

ELTAYAR, N ^{[1
]}

TSAI, RS ^{[1
]}

VALLAT, P ^{[1
]}

ALTOMARE, C ^{[1
]}

TESTA, B ^{[1
]}

机构：

[1] UNIV LAUSANNE,ECOLE PHARM,INST CHIM THERAPEUT,BEP,CH-1015 LAUSANNE,SWITZERLAND

来源：

JOURNAL OF CHROMATOGRAPHY | 1991年 / 556卷 / 1-2期

关键词：

D O I：

10.1016/S0021-9673(01)96220-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Using published and previously unpublished data, the present paper compares the value of four centrifugal partition chromatography systems for measuring partition coefficients. The best results (broad applicability, log P range -3 to +3, precision, effectiveness) were obtained with the Ito multilayer coil separator-extractor and the horizontal flow-through multilayer centrifugal partition chromatography model. Excellent correlations were found with published log P values obtained by the shake-flask method.

引用

页码：181 / 194

页数：14

共 45 条

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