MEASUREMENT OF PARTITION-COEFFICIENTS BY VARIOUS CENTRIFUGAL PARTITION CHROMATOGRAPHIC TECHNIQUES - A COMPARATIVE-EVALUATION

被引：57

作者：

ELTAYAR, N ^{[1
]}

TSAI, RS ^{[1
]}

VALLAT, P ^{[1
]}

ALTOMARE, C ^{[1
]}

TESTA, B ^{[1
]}

机构：

[1] UNIV LAUSANNE,ECOLE PHARM,INST CHIM THERAPEUT,BEP,CH-1015 LAUSANNE,SWITZERLAND

来源：

JOURNAL OF CHROMATOGRAPHY | 1991年 / 556卷 / 1-2期

关键词：

D O I：

10.1016/S0021-9673(01)96220-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Using published and previously unpublished data, the present paper compares the value of four centrifugal partition chromatography systems for measuring partition coefficients. The best results (broad applicability, log P range -3 to +3, precision, effectiveness) were obtained with the Ito multilayer coil separator-extractor and the horizontal flow-through multilayer centrifugal partition chromatography model. Excellent correlations were found with published log P values obtained by the shake-flask method.

引用

页码：181 / 194

页数：14

共 45 条

[1] DETERMINATION OF LIPOPHILICITY AND HYDROGEN-BOND DONOR ACIDITY OF BIOACTIVE SULFONYL-CONTAINING COMPOUNDS BY REVERSED-PHASE HPLC AND CENTRIFUGAL PARTITION CHROMATOGRAPHY AND THEIR APPLICATION TO STRUCTURE-ACTIVITY RELATIONS [J].

ALTOMARE, C ;

TSAI, RS ;

ELTAYAR, N ;

TESTA, B ;

CAROTTI, A ;

CELLAMARE, S ;

DEBENEDETTI, PG .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1991, 43 (03) :191-197

[2] STUDY OF THE ORIGIN AND MECHANISM OF BAND BROADENING AND PRESSURE-DROP IN CENTRIFUGAL COUNTERCURRENT CHROMATOGRAPHY [J].

ARMSTRONG, DW ;

BERTRAND, GL ;

BERTHOD, A .

ANALYTICAL CHEMISTRY, 1988, 60 (22) :2513-2519

[3] SILANOPHILIC INTERACTIONS IN REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

BAYER, E ;

PAULUS, A .

JOURNAL OF CHROMATOGRAPHY, 1987, 400 :1-4

[4]

Berthelot M., 1872, ANN CHIM PHYS, V26, P396

[5] CENTRIFUGAL PARTITION CHROMATOGRAPHY .2. SELECTIVITY AND EFFICIENCY [J].

BERTHOD, A ;

ARMSTRONG, DW .

JOURNAL OF LIQUID CHROMATOGRAPHY, 1988, 11 (03) :567-583

[6] CENTRIFUGAL PARTITION CHROMATOGRAPHY .1. GENERAL FEATURES [J].

BERTHOD, A ;

ARMSTRONG, DW .

JOURNAL OF LIQUID CHROMATOGRAPHY, 1988, 11 (03) :547-566

[7] DETERMINATION OF HYDROPHOBIC PARAMETERS BY REVERSED-PHASE LIQUID-CHROMATOGRAPHY - THEORY, EXPERIMENTAL-TECHNIQUES, AND APPLICATION IN STUDIES ON QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS [J].

BRAUMANN, T .

JOURNAL OF CHROMATOGRAPHY, 1986, 373 (02) :191-225

[8]

CONWAY WD, 1984, LC LIQ CHROMATOGR HP, V2, P368

[9]

DEARDEN J C, 1985, Journal of Pharmacy and Pharmacology, V37, p70P

[10] THE MEASUREMENT OF PARTITION-COEFFICIENTS [J].

DEARDEN, JC ;

BRESNEN, GM .

QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS, 1988, 7 (03) :133-144

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