ANALYSIS OF COUMARINS BY MICRO-HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY WITH A PARTICLE-BEAM INTERFACE

被引：26
作者：
CAPPIELLO, A [1 ]
FAMIGLINI, G [1 ]
MANGANI, F [1 ]
TIRILLINI, B [1 ]
机构：
[1] UNIV URBINO,IST BOT & ORTO BOT,I-61029 URBINO,ITALY
来源：
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | 1995年 / 6卷 / 02期
关键词：
D O I：
10.1016/S1044-0305(94)00096-I
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Coumarins are a large group of compounds that are naturally present in plant tissues and that exhibit a wide range of pharmacological properties. Analytical methods based on chromatographic techniques and conventional detectors are inadequate to accurately analyze coumarins in complex matrices such as plant extracts. In this article a new method based on a modified particle beam liquid chromatography-mass spectrometry interface is described. The method allows specific and accurate determination of several coumarins in biological matrices. An application regarding the analysis of 18 coumarins in the extract of Smyrnium perfoliatum L. is also reported.
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页码：132 / 139
页数：8
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