NONINVASIVE CEREBRAL OPTICAL SPECTROSCOPY - DEPTH-RESOLVED MEASUREMENTS OF CEREBRAL HEMODYNAMICS USING INDOCYANINE GREEN

被引:108
作者
HONGO, K
KOBAYASHI, S
OKUDERA, H
HOKAMA, M
NAKAGAWA, F
机构
[1] SHINSHU UNIV,SCH MED,DEPT NEUROSURG,MATSUMOTO,NAGANO 390,JAPAN
[2] SHINONOI GEN HOSP,NAGANO,JAPAN
[3] TOYOSHINA RED CROSS HOSP,TOYOSHINA,JAPAN
关键词
CEREBRAL BLOOD FLOW (CBF); CEREBRAL BLOOD VOLUME (CBV); CEREBRAL HEMODYNAMICS; NEAR-INFRARED SPECTROSCOPY (NIRS); NONINVASIVE; CEREBRAL OXIMETRY;
D O I
10.1080/01616412.1995.11740293
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
To investigate the feasibility of a newly developed, near-infrared optical spectroscopy device, we analysed measurements of the infrared tracer indocyanine green (ICG) using sensors with a single near infrared light source and multiple light detectors. Two mi of ICC dye, 1.0 mg ml(-1) in concentration, were injected into the internal carotid artery during cerebral angiography in 14 adult patients. The resultant washout curves were measured bilaterally using sensors with 4 detectors spaced at 10, 20, 30 and 40 mm from the infrared light source on the right side, and 15, 25, 35 and 45 mm from the source for the left side, respectively. Washout curves were analysed to determine the relative amplitude of the ICC absorption signal and deduce each detector's penetration distance. When ICC was injected into the internal carotid artery, relative absorption increased with detector distance from the light source. No substantial difference in attenuation was observed in any of the detectors during external carotid injection of ICC. The resultant information related depth of penetration of the light with source-detector separation distances. The feasibility of the system for measuring cerebral oxygen saturation and haemodynamics noninvasively or monitoring at bedside is discussed.
引用
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页码:89 / 93
页数:5
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