SYNTHESIS OF CARBOHYDRATES VIA TANDEM USE OF THE OSMIUM-CATALYZED ASYMMETRIC DIHYDROXYLATION AND ENZYME-CATALYZED ALDOL ADDITION-REACTIONS

被引：65

作者：

HENDERSON, I ^{[1
]}

SHARPLESS, KB ^{[1
]}

WONG, CH ^{[1
]}

机构：

[1] Scripps Res Inst, DEPT CHEM, 10666 N TORREY PINES RD, LA JOLLA, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1994年 / 116卷 / 02期

关键词：

D O I：

10.1021/ja00081a016

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new strategy is described for the asymmetric synthesis of carbohydrate derivatives via the tandem use of the osmium-catalyzed asymmetric dihydroxylation (AD) and aldolase-catalyzed aldol addition reactions. Both D- and L-forms of fructose, 6-deoxy-galacto-2-heptulose, and 6-phenyl-galacto-2-hexulose were synthesized to illustrate this methodology.

引用

页码：558 / 561

页数：4

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