INCREASED GENERATION OF CYSTEINYL LEUKOTRIENES IN KAWASAKI-DISEASE

被引：13

作者：

MAYATEPEK, E ^{[1
]}

LEHMANN, WD ^{[1
]}

机构：

[1] GERMAN CANC RES CTR,DEPT CENT SPECT,W-6900 HEIDELBERG,GERMANY

来源：

ARCHIVES OF DISEASE IN CHILDHOOD | 1995年 / 72卷 / 06期

关键词：

KAWASAKI DISEASE; CYSTEINYL LEUKOTRIENES; LEUKOTRIENE;

D O I：

10.1136/adc.72.6.526

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Endogenous cysteinyl leukotriene synthesis was assessed in 10 patients with Kawasaki disease and 10 healthy controls by measuring excretion of leukotriene E(4) (LTE(4)) in urine. LTE(4) was increased more than fivefold in patients with Kawasaki disease compared with controls (median (range) 55.3 (31.8-120.6) v 10.2 (7.1-14.9) nmol/mol creatinine); this suggests that cysteinyl leukotrienes are involved in the pathophysiology of Kawasaki disease. Leukotriene synthetase inhibition or receptor antagonism may therefore offer a new potential therapeutic approach in children with this disease.

引用

页码：526 / 527

页数：2

共 7 条

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