SEROTONIN-5-O-CARBOXYMETHYL-GLYCYL[I-125]TYROSINAMIDE LABELS THE 5-HT(1D-BETA)-RECEPTOR SUBTYPE IN HUMAN CORTEX

被引：17

作者：

BEER, MS

MIDDLEMISS, DN

机构：

[1] Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex CM20 2QR, Terlings Park, Eastwick Road

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 242卷 / 02期

关键词：

SEROTONIN-5-O-CARBOXYMETHYL-GLYCYL[I-125]TYROSINAMIDE ([I-125]GTI); 5-HT(1D-ALPHA/BETA)-RECEPTORS; CEREBRAL CORTEX (HUMAN);

D O I：

10.1016/0014-2999(93)90080-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study, carried out in human cerebral cortical membranes, confirms previous findings in human substantia nigra that serotonin-5-O-carboxymethyl-glycyl[I-125]tyrosinamide ([I-125]GTI) labels a homogeneous population of recognition sites consistent with a 5-HT1D receptor pharmacology. In addition the results indicate that, under the assay conditions described, [I-125]GTI specifically labels the 5-HT1Dbeta recognition site since ketanserin and ritanserin display a low affinity consistent with their activities at this subtype of the 5-HT1D receptor.

引用

页码：195 / 198

页数：4