THE ROLE OF T(H)1 AND T(H)2 CELLS IN A RODENT MALARIA INFECTION

被引：342
作者：
TAYLORROBINSON, AW
PHILLIPS, RS
SEVERN, A
MONCADA, S
LIEW, FY
机构：
[1] UNIV GLASGOW,DEPT IMMUNOL,GLASGOW G11 6NT,SCOTLAND
[2] WELLCOME RES LABS,BECKENHAM BR3 3BS,KENT,ENGLAND
来源：
SCIENCE | 1993年 / 260卷 / 5116期
基金：
英国惠康基金;
关键词：
D O I：
10.1126/science.8100366
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
CD4+ T cells play a major role in protective immunity against the blood stage of malaria, but the mechanism of protection is unclear. By adoptive transfer of cloned T cell lines, direct evidence is provided that both T(H)1 and T(H)2 subsets of CD4+ T cells can protect mice against Plasmodium chabaudi chabaudi infection. T(H)1 cells protect by a nitric oxide-dependent mechanism, whereas T(H)2 cells protect by the enhancement and accelerated production of specific immunoglobulin G1 antibody.
引用
收藏
页码：1931 / 1934
页数：4
相关论文
共 22 条
[1]   THERAPY WITH MONOCLONAL-ANTIBODIES BY ELIMINATION OF T-CELL SUBSETS INVIVO [J].
COBBOLD, SP ;
JAYASURIYA, A ;
NASH, A ;
PROSPERO, TD ;
WALDMANN, H .
NATURE, 1984, 312 (5994) :548-551
[2]   NITRIC-OXIDE AS A SIGNAL IN BLOOD-VESSELS [J].
KNOWLES, RG ;
MONCADA, S .
TRENDS IN BIOCHEMICAL SCIENCES, 1992, 17 (10) :399-402
[3]   THE ROLE OF CD4+ T-CELLS IN THE IMMUNE-RESPONSE TO PLASMODIUM-CHABAUDI [J].
LANGHORNE, J .
PARASITOLOGY TODAY, 1989, 5 (11) :362-364
[4]  
LEIST TP, 1984, J IMMUNOL, V138, P548
[5]   A POSSIBLE NOVEL PATHWAY OF REGULATION BY MURINE T-HELPER TYPE-2 (TH2) CELLS OF A TH1 CELL-ACTIVITY VIA THE MODULATION OF THE INDUCTION OF NITRIC-OXIDE SYNTHASE ON MACROPHAGES [J].
LIEW, FY ;
LI, Y ;
SEVERN, A ;
MILLOTT, S ;
SCHMIDT, J ;
SALTER, M ;
MONCADA, S .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1991, 21 (10) :2489-2494
[6]   MACROPHAGE OXIDATION OF L-ARGININE TO NITRITE AND NITRATE - NITRIC-OXIDE IS AN INTERMEDIATE [J].
MARLETTA, MA ;
YOON, PS ;
IYENGAR, R ;
LEAF, CD ;
WISHNOK, JS .
BIOCHEMISTRY, 1988, 27 (24) :8706-8711
[7]   PLASMODIUM-CHABAUDI - ANTIGENIC VARIATION DURING RECRUDESCENT PARASITEMIAS IN MICE [J].
MCLEAN, SA ;
PEARSON, CD ;
PHILLIPS, RS .
EXPERIMENTAL PARASITOLOGY, 1982, 54 (03) :296-302
[8]   PLASMODIUM-CHABAUDI - RELATIONSHIP BETWEEN THE OCCURRENCE OF RECRUDESCENT PARASITEMIAS IN MICE AND THE EFFECTIVE LEVELS OF ACQUIRED-IMMUNITY [J].
MCLEAN, SA ;
PEARSON, CD ;
PHILLIPS, RS .
EXPERIMENTAL PARASITOLOGY, 1982, 54 (02) :213-221
[9]  
MELLOUK S, 1991, J IMMUNOL, V146, P3971
[10]   STUDIES ON HETEROLOGOUS ANTI-LYMPHOCYTE SERUM IN MICE .3. IMMUNOLOGIC TOLERANCE AND CHIMERISM PRODUCED ACROSS H-2 LOCUS WITH ADULT THYMECTOMY AND ANTI-LYMPHOCYTE SERUM [J].
MONACO, AP ;
WOOD, ML ;
RUSSELL, PS .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES, 1966, 129 (A1) :190-+
123