COMPARATIVE TRIAL OF ORAL CLOTRIMAZOLE AND NYSTATIN FOR OROPHARYNGEAL CANDIDIASIS PROPHYLAXIS IN ORTHOTOPIC LIVER-TRANSPLANT PATIENTS

被引：25

作者：

RUSKIN, JD

WOOD, RP

BAILEY, MR

WHITMORE, CK

SHAW, BW

机构：

[1] UNIV NEBRASKA,MED CTR,DEPT SURG,ORAL & MAXILLOFACIAL SURG SECT,OMAHA,NE 68105

[2] UNIV TEXAS,DEPT SURG,TRANSPLANT SURG SECT,AUSTIN,TX 78712

[3] HOECHST ROUSSEL PHARMACEUT PTY LTD,SOMERVILLE,NJ 08876

来源：

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS | 1992年 / 74卷 / 05期

关键词：

D O I：

10.1016/0030-4220(92)90345-Q

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

A prospective randomized study was conducted to assess the effectiveness of clotrimazole troches and nystatin suspension to prevent oral candidiasis in immunosuppressed orthotopic liver transplant patients. Thirty-four patients received either clotrimazole troches, 10 mg, five times daily, or nystatin suspension, 500,000 units, four times daily. Prophylaxis was initiated after extubation after transplantation and continued throughout the hospitalization. One of 17 patients in each treatment group developed clinical and microscopic evidence of an oropharyngeal Candida infection. This gave an intragroup and an overall infection rate of 5.9%. It appears that either nystatin or clotrimazole may be used for candidiasis prophylaxis in orthotopic liver transplant patients.

引用

页码：567 / 571

页数：5

共 21 条

[1]

Dreizen, Oral candidiasis, Am J Med, 77, pp. 28-33, (1984)

[2]

Trier, Bjorkman, Esophageal, gastric and intestinal candidiasis, Am J Med, 77, pp. 39-43, (1984)

[3]

Ho, Wajszczuk, Hardy, Et al., Infections in kidney, heart, and liver transplant recipients on cyclosporine, Transplant Proc, 15, 4, pp. 2768-2772, (1983)

[4]

Goodrich, Reed, Mori, Et al., Clinical features and analysis of risk factors for invasive candidal infection after marrow transplantation, JID, 164, pp. 731-740, (1991)

[5]

Verfaille, Weisdorf, Haake, Hostetter, Ramsay, McGlave, Candida infections in bone marrow recipients, Bone Marrow Transplant, 8, pp. 177-184, (1991)

[6]

Winston, Gale, Meyer, Young, Infectious complications of human marrow transplantation, Medicine, 58, pp. 1-31, (1979)

[7]

Pirsch, Maki, Infectious complications in adults with bone marrow transplantation and T-cell depletion of donor marrow, Intern Med, 104, (1988)

[8]

Wajszczuk, Dummer, Ho, Et al., Fungal infections in liver transplant recipients, Transplantation, 40, pp. 347-363, (1985)

[9]

Kusne, Dummer, Singh, Et al., Infections after liver transplantation: an analysis of 101 consecutive cases, Medicine, 67, pp. 132-143, (1988)

[10]

Colonna, Winston, Brill, Et al., Infectious complications in liver transplantation, Arch Surg, 123, pp. 360-364, (1988)

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