ENZYMES IN ORGANIC-SYNTHESIS .15. SYNTHESIS OF METHYL (S)-(-)-2,3-O-ISOPROPYLIDENEGLYCERATE BY ENANTIOSELECTIVE ENZYME-CATALYZED HYDROLYSIS OF METHYL (+/-)-2,3-O-ISOPROPYLIDENEGLYCERATE

被引：0

作者：

SCHICK, H ^{[1
]}

SCHROTTER, E ^{[1
]}

SZYMANOWSKI, M ^{[1
]}

KNOLL, A ^{[1
]}

机构：

[1] RES CTR BIOTECHNOL,O-1017 BERLIN,GERMANY

来源：

LIEBIGS ANNALEN DER CHEMIE | 1993年 / 01期

关键词：

ENZYMES; PROTEASES; ESTER HYDROLYSIS; ENZYMATIC; ISOPROPYLIDENEGLYCERATES; RESOLUTION; KINETIC; GLYCERATES;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In contrast to porcine pancreatic lipase (PPL), the serine proteases aP 41 and thermitase are suited as catalysts for the enantioselective ester hydrolysis of methyl (+/-)-2,3-O-isopropylideneglycerate (rac-1). These enzymes allow the preparation of methyl (S)-(-)-2,3-O-isopropylideneglycerate (1) with an enantiomeric excess of 84-87% in a yield of 19-27% related to the starting racemate.

引用

页码：103 / 104

页数：2

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