THE CML-SPECIFIC P210 BCR/ABL PROTEIN, UNLIKE V-ABL, DOES NOT TRANSFORM NIH/3T3 FIBROBLASTS

被引：145
作者：
DALEY, GQ
MCLAUGHLIN, J
WITTE, ON
BALTIMORE, D
机构：
[1] UNIV CALIF LOS ANGELES,INST MOLEC BIOL,LOS ANGELES,CA 90024
[2] UNIV CALIF LOS ANGELES,HOWARD HUGHES MED INST,DEPT MICROBIOL,LOS ANGELES,CA 90024
[3] MIT,DEPT ENVIRONM & FOREST BIOL,CAMBRIDGE,MA 02139
来源：
SCIENCE | 1987年 / 237卷 / 4814期
关键词：
D O I：
10.1126/science.2440107
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
引用
收藏
页码：532 / 535
页数：4
相关论文
共 43 条
[11]   PHILADELPHIA CHROMOSOMAL BREAKPOINTS ARE CLUSTERED WITHIN A LIMITED REGION, BCR, ON CHROMOSOME-22 [J].
GROFFEN, J ;
STEPHENSON, JR ;
HEISTERKAMP, N ;
DEKLEIN, A ;
BARTRAM, CR ;
GROSVELD, G .
CELL, 1984, 36 (01) :93-99
[12]   CDNA SEQUENCE FOR HUMAN-BCR, THE GENE THAT TRANSLOCATES TO THE ABL-ONCOGENE IN CHRONIC MYELOID-LEUKEMIA [J].
HARIHARAN, IK ;
ADAMS, JM .
EMBO JOURNAL, 1987, 6 (01) :115-119
[13]  
JACKSON P, UNPUB
[14]   CELL-LINES AND CLINICAL ISOLATES DERIVED FROM PH1-POSITIVE CHRONIC MYELOGENOUS LEUKEMIA PATIENTS EXPRESS C-ABL PROTEINS WITH A COMMON STRUCTURAL ALTERATION [J].
KONOPKA, JB ;
WATANABE, SM ;
SINGER, JW ;
COLLINS, SJ ;
WITTE, ON .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (06) :1810-1814
[15]   ONLY SITE-DIRECTED ANTIBODIES REACTIVE WITH THE HIGHLY CONSERVED SRC-HOMOLOGOUS REGION OF THE V-ABL PROTEIN NEUTRALIZE KINASE-ACTIVITY [J].
KONOPKA, JB ;
DAVIS, RL ;
WATANABE, SM ;
PONTICELLI, AS ;
SCHIFFMAKER, L ;
ROSENBERG, N ;
WITTE, ON .
JOURNAL OF VIROLOGY, 1984, 51 (01) :223-232
[16]   AN ALTERATION OF THE HUMAN C-ABL PROTEIN IN K562 LEUKEMIA-CELLS UNMASKS ASSOCIATED TYROSINE KINASE-ACTIVITY [J].
KONOPKA, JB ;
WATANABE, SM ;
WITTE, ON .
CELL, 1984, 37 (03) :1035-1042
[17]   DETECTION OF C-ABL TYROSINE KINASE-ACTIVITY INVITRO PERMITS DIRECT COMPARISON OF NORMAL AND ALTERED ABL GENE-PRODUCTS [J].
KONOPKA, JB ;
WITTE, ON .
MOLECULAR AND CELLULAR BIOLOGY, 1985, 5 (11) :3116-3123
[18]   A NOVEL C-ABL PROTEIN PRODUCT IN PHILADELPHIA-POSITIVE ACUTE LYMPHOBLASTIC-LEUKEMIA [J].
KURZROCK, R ;
SHTALRID, M ;
ROMERO, P ;
KLOETZER, WS ;
TALPAS, M ;
TRUJILLO, JM ;
BLICK, M ;
BERAN, M ;
GUTTERMAN, JU .
NATURE, 1987, 325 (6105) :631-635
[19]   CLONING AND ANALYSIS OF REVERSE TRANSCRIPT P160 GENOMES OF ABELSON MURINE LEUKEMIA-VIRUS [J].
LATT, SA ;
GOFF, SP ;
TABIN, CJ ;
PASKIND, M ;
WANG, JYJ ;
BALTIMORE, D .
JOURNAL OF VIROLOGY, 1983, 45 (03) :1195-1199
[20]  
LOGGIO CB, 1975, BLOOD, V45, P321
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