DESTABILIZATION OF EGG LECITHIN LIPOSOMES ON THE SKIN AFTER TOPICAL APPLICATION MEASURED BY PERTURBED GAMMA-GAMMA ANGULAR-CORRELATION SPECTROSCOPY (PAC) WITH IN-111

Unilamellar and oligolamellar liposomes were topically applied to the skin of porcine ears. Perturbed angular correlation spectroscopy of In-111-DTPA, initially entrapped into the liposomes, was used to study the release kinetics of the hydrophilic probe. After drying of the liposomal suspensions, a decrease of the time-integrated perturbation factor [G22(infinity)] within 30 min indicated destabilization of the liposomes and total marker release in the upper epidermal layers.