EFFECTS OF APELIN-12 AND OBESTATIN OF LEFT VENTRICULAR HYPERTROPHY IN PATIENTS WITH ARTERIAL HYPERTENSION DEPENDING ON THE DURATION OF DIABETES MELLITUS TYPE 2

The prevalence of left ventricular hypertrophy associated with arterial hypertension, obesity, diseases of the cardiovascular system, metabolic disorders, diabetes mellitus. The aim of the study was to assess the presence and character of links between apelin-12, obestatin and cardiac hemodynamics parameters for analyzing the effects of these humoral markers on the of left ventricular hypertrophy in patients with arterial hypertension and diabetes mellitus type 2. Severity of left ventricular hypertrophy by parameter left ventricular mass index grew in proportion to the duration of diabetes mellitus type 2 in patients with arterial hypertension. The presence of diabetes mellitus type 2 less than 5 years duration is associated with adaptive apelin-12 and obestatin high activity in patients with arterial hypertension. The presence of the disease with diabetes mellitus type 2 over 5 years in hypertensive patients accompanied by depletion of compensatory reactions of obestatin, and in long-term diabetes mellitus type 2 (over 10 years) - at the expense of obestatin and apelin-12 leads to an increase in the degree of left ventricular hypertrophy in hypertensive patients.