DROSOPHILA-MELANOGASTER DIPHENOL OXIDASE A2 - GENE STRUCTURE AND HOMOLOGY WITH THE MOUSE MAST-CELL TUM- TRANSPLANTATION ANTIGEN, P91A

被引：28

作者：

PENTZ, ES ^{[1
]}

WRIGHT, TRF ^{[1
]}

机构：

[1] UNIV VIRGINIA,INST MOLEC BIOL,CHARLOTTESVILLE,VA 22901

来源：

GENE | 1991年 / 103卷 / 02期

关键词：

RECOMBINANT DNA; SCLEROTIZATION; CATECHOLAMINE METABOLISM; MELANIZATION; PHENOL OXIDASES; TYROSINASES; IMMUNOGENIC MUTANTS;

D O I：

10.1016/0378-1119(91)90279-K

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The Drosophila melanogaster diphenol oxidase (DOX) A2-encoding gene (Dox-A2) is involved in catecholamine metabolism, melanin formation and sclerotization of the cuticle. Insect phenol oxidases (POX) are well studied biochemically, but not genetically and molecularly. The Dox-A2 (2-53.9) gene is the first insect POX-encoding gene to be cloned and sequenced. It encodes a protein product unique among currently known POX. The deduced protein, however, exhibits extensive similarity (58-81%) to the mouse mast cell tum- antigen, P91A [Lurquin et al., Cell 58 (1989) 293-303] and may identify the normal mouse protein as a DOX.

引用

页码：239 / 242

页数：4

共 18 条

[1] THE ALPHA-AMYLASE GENE IN DROSOPHILA-MELANOGASTER - NUCLEOTIDE-SEQUENCE, GENE STRUCTURE AND EXPRESSION MOTIFS [J].

BOER, PH ;

HICKEY, DA .

NUCLEIC ACIDS RESEARCH, 1986, 14 (21) :8399-8411

[2] FUNCTIONAL CDNA LIBRARIES FROM DROSOPHILA EMBRYOS [J].

BROWN, NH ;

KAFATOS, FC .

JOURNAL OF MOLECULAR BIOLOGY, 1988, 203 (02) :425-437

[3] COMPARISON OF THE CONSENSUS SEQUENCE FLANKING TRANSLATIONAL START SITES IN DROSOPHILA AND VERTEBRATES [J].

CAVENER, DR .

NUCLEIC ACIDS RESEARCH, 1987, 15 (04) :1353-1361

[4]

DENG Y, 1989, 16TH P INT C GEN GEN, V31, P192

[5] ISOLATION AND PARTIAL NUCLEOTIDE-SEQUENCE OF THE LACCASE GENE FROM NEUROSPORA-CRASSA - AMINO-ACID-SEQUENCE HOMOLOGY OF THE PROTEIN TO HUMAN CERULOPLASMIN [J].

GERMANN, UA ;

LERCH, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (23) :8854-8858

[6] GRANULAR PHENOLOXIDASE INVOLVED IN CUTICULAR MELANIZATION IN THE TOBACCO HORNWORM - REGULATION OF ITS SYNTHESIS IN THE EPIDERMIS BY JUVENILE-HORMONE [J].

HIRUMA, K ;

RIDDIFORD, LM .

DEVELOPMENTAL BIOLOGY, 1988, 130 (01) :87-97

[7]

HORII A, 1987, GENE, V60, P57

[8] STRUCTURE OF THE GENE OF TUM- TRANSPLANTATION ANTIGEN-P91A - THE MUTATED EXON ENCODES A PEPTIDE RECOGNIZED WITH LD BY CYTOLYTIC T-CELLS [J].

LURQUIN, C ;

VANPEL, A ;

MARIAME, B ;

DEPLAEN, E ;

SZIKORA, JP ;

JANSSENS, C ;

REDDEHASE, MJ ;

LEJEUNE, J ;

BOON, T .

CELL, 1989, 58 (02) :293-303

[9] IMPROVED TOOLS FOR BIOLOGICAL SEQUENCE COMPARISON [J].

PEARSON, WR ;

LIPMAN, DJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (08) :2444-2448

[10] MUTATIONS AFFECTING PHENOL OXIDASE ACTIVITY IN DROSOPHILA, QUICKSILVER AND TYROSINASE-1 [J].

PENTZ, ES ;

BLACK, BC ;

WRIGHT, TRF .

BIOCHEMICAL GENETICS, 1990, 28 (3-4) :151-171

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